Cargando…

The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses

BACKGROUND: Equine metabolic syndrome (EMS) is a multifactorial pathology gathering insulin resistance, low-grade inflammation and past or chronic laminitis. Among the several molecular mechanisms underlying EMS pathogenesis, increased negative insulin signalling regulation mediated by protein tyros...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bourebaba, Lynda, Serwotka-Suszczak, Anna, Pielok, Ariadna, Sikora, Mateusz, Mularczyk, Malwina, Marycz, Krzysztof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067883/ https://www.ncbi.nlm.nih.gov/pubmed/37020593 http://dx.doi.org/10.3389/fendo.2023.1149610

Ejemplares similares

The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity
por: Bourebaba, Lynda, et al.
Publicado: (2023)

In Vitro Generated Equine Hepatic-Like Progenitor Cells as a Novel Potent Cell Pool for Equine Metabolic Syndrome (EMS) Treatment
por: Marycz, Krzysztof, et al.
Publicado: (2023)

Sex Hormone-Binding Globulin (SHBG) Maintains Proper Equine Adipose-Derived Stromal Cells (ASCs)’ Metabolic Functions and Negatively Regulates their Basal Adipogenic Potential
por: Bourebaba, Lynda, et al.
Publicado: (2023)

The PTP1B selective inhibitor MSI-1436 mitigates Tunicamycin-induced ER stress in human hepatocarcinoma cell line through XBP1 splicing modulation
por: Bourebaba, Lynda, et al.
Publicado: (2023)

Astaxanthin Carotenoid Modulates Oxidative Stress in Adipose-Derived Stromal Cells Isolated from Equine Metabolic Syndrome Affected Horses by Targeting Mitochondrial Biogenesis
por: Mularczyk, Malwina, et al.
Publicado: (2022)

MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress
por: Bourebaba, Lynda, et al.
Publicado: (2021)

Sex hormone-binding globulin (SHBG) mitigates ER stress and improves viability and insulin sensitivity in adipose-derived mesenchymal stem cells (ASC) of equine metabolic syndrome (EMS)-affected horses
por: Bourebaba, Nabila, et al.
Publicado: (2023)

Equine Hoof Progenitor Cells Display Increased Mitochondrial Metabolism and Adaptive Potential to a Highly Pro-Inflammatory Microenvironment
por: Pielok, Ariadna, et al.
Publicado: (2023)

Obesity Affects the Proliferative Potential of Equine Endometrial Progenitor Cells and Modulates Their Molecular Phenotype Associated with Mitochondrial Metabolism
por: Smieszek, Agnieszka, et al.
Publicado: (2022)

MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM/P6 mice
por: Sikora, Mateusz, et al.
Publicado: (2023)

Osteochondritis dissecans (OCD) in Horses – Molecular Background of its Pathogenesis and Perspectives for Progenitor Stem Cell Therapy
por: Bourebaba, Lynda, et al.
Publicado: (2019)

Equine Hoof Stem Progenitor Cells (HPC) CD29 + /Nestin + /K15 + – a Novel Dermal/epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment
por: Marycz, Krzysztof, et al.
Publicado: (2021)

Inhibition of Protein-Tyrosine Phosphatase PTP1B and LMPTP Promotes Palmitate/Oleate-Challenged HepG2 Cell Survival by Reducing Lipoapoptosis, Improving Mitochondrial Dynamics and Mitigating Oxidative and Endoplasmic Reticulum Stress
por: Bourebaba, Lynda, et al.
Publicado: (2020)

The Role of miR-21 in Osteoblasts–Osteoclasts Coupling In Vitro
por: Smieszek, Agnieszka, et al.
Publicado: (2020)

The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues
por: Smith, Ashley M., et al.
Publicado: (2017)

Calystegines Improve the Metabolic Activity of Human Adipose Derived Stromal Stem Cells (ASCs) under Hyperglycaemic Condition through the Reduction of Oxidative/ER Stress, Inflammation, and the Promotion of the AKT/PI3K/mTOR Pathway
por: Kowalczuk, Anna, et al.
Publicado: (2022)

Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo
por: Kornicka-Garbowska, Katarzyna, et al.
Publicado: (2021)

Nanohydroxyapatite-Mediated Imatinib Delivery for Specific Anticancer Applications
por: Sobierajska, Paulina, et al.
Publicado: (2020)

Nortropane alkaloids as pharmacological chaperones in the rescue of equine adipose-derived mesenchymal stromal stem cells affected by metabolic syndrome through mitochondrial potentiation, endoplasmic reticulum stress mitigation and insulin resistance alleviation
por: Bourebaba, Lynda, et al.
Publicado: (2019)

Cladophora glomerata methanolic extract promotes chondrogenic gene expression and cartilage phenotype differentiation in equine adipose-derived mesenchymal stromal stem cells affected by metabolic syndrome
por: Bourebaba, Lynda, et al.
Publicado: (2019)

Non-Coding RNAs as Potential Novel Biomarkers for Early Diagnosis of Hepatic Insulin Resistance
por: Pielok, Ariadna, et al.
Publicado: (2020)

Synergistic Effect of Toceranib and Nanohydroxyapatite as a Drug Delivery Platform—Physicochemical Properties and In Vitro Studies on Mastocytoma Cells
por: Sobierajska, Paulina, et al.
Publicado: (2022)

Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review
por: Bourebaba, Lynda, et al.
Publicado: (2019)

Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
por: Mularczyk, Malwina, et al.
Publicado: (2020)

Zirconium Oxide Thin Films Obtained by Atomic Layer Deposition Technology Abolish the Anti-Osteogenic Effect Resulting from miR-21 Inhibition in the Pre-Osteoblastic MC3T3 Cell Line
por: Seweryn, Aleksandra, et al.
Publicado: (2020)

Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway
por: Kowalczuk, Anna, et al.
Publicado: (2021)

Correction: Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway
por: Kowalczuk, Anna, et al.
Publicado: (2023)

The Dynamics of Circulating Immune Complexes in Horses with Severe Equine Asthma
por: Slowikowska, Malwina, et al.
Publicado: (2021)

Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells
por: Kornicka-Garbowska, Katarzyna, et al.
Publicado: (2021)

The Hepatic Stellate Cells (HSTCs) and Adipose-derived Mesenchymal Stem Cells (ASCs) Axis as a Potential Major Driver of Metabolic Syndrome – Novel Concept and Therapeutic Implications
por: Marycz, Krzysztof, et al.
Publicado: (2021)

Correction: Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells
por: Kornicka-Garbowska, Katarzyna, et al.
Publicado: (2023)

Tetrahydrocannabivarin (THCV) Protects Adipose-Derived Mesenchymal Stem Cells (ASC) against Endoplasmic Reticulum Stress Development and Reduces Inflammation during Adipogenesis
por: Kowalczuk, Anna, et al.
Publicado: (2023)

Complete genome sequence of the sand-sediment actinobacterium Nocardioides dokdonensis FR1436(T)
por: Kwak, Min-Jung, et al.
Publicado: (2017)

P1436: AGEING IMPACTS HYDROXYCARBAMIDE DOSING IN PATIENTS WITH SICKLE CELL DISEASE
por: Doss, Isabelle, et al.
Publicado: (2023)

Equine Metabolic Syndrome Affects Viability, Senescence, and Stress Factors of Equine Adipose-Derived Mesenchymal Stromal Stem Cells: New Insight into EqASCs Isolated from EMS Horses in the Context of Their Aging
por: Marycz, Krzysztof, et al.
Publicado: (2016)

1436. Interventions to Address the Global Underreporting of Pediatric and Adolescent Tuberculosis: A Systematic Review
por: Linn, Alexandra R, et al.
Publicado: (2022)

Cladophora glomerata enriched by biosorption with Mn(II) ions alleviates lipopolysaccharide‐induced osteomyelitis‐like model in MC3T3‐E1, and 4B12 osteoclastogenesis
por: Bourebaba, Lynda, et al.
Publicado: (2020)

Extracellular Microvesicles (MV’s) Isolated from 5-Azacytidine-and-Resveratrol-Treated Cells Improve Viability and Ameliorate Endoplasmic Reticulum Stress in Metabolic Syndrome Derived Mesenchymal Stem Cells
por: Weiss, C, et al.
Publicado: (2020)

Evaluation of Oxidative Stress and Mitophagy during Adipogenic Differentiation of Adipose-Derived Stem Cells Isolated from Equine Metabolic Syndrome (EMS) Horses
por: Marycz, Krzysztof, et al.
Publicado: (2018)

Correction: Serwotka-Suszczak, A. M. et al. A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells. Int. J. Mol. Sci. 2017, 18, 401
por: Serwotka-Suszczak, Anna M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t774it24eol7jf0ogk2e2k938k