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Effective differentiation of double negative thymocytes requires high fidelity replication of mitochondrial DNA in an age dependent manner

One of the most proliferative periods for T cells occurs during their development in the thymus. Increased DNA replication can result in increased DNA mutations in the nuclear genome, but also in mitochondrial genomes. A high frequency of mitochondrial DNA mutations can lead to abnormal mitochondria...

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Detalles Bibliográficos
Autores principales:	Limper, Candice B., Bondah, Narda, Zhu, Daphne, Villanueva, Alanis N., Chukwukere, Uchenna K., Huang, Weishan, August, Avery
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067910/ https://www.ncbi.nlm.nih.gov/pubmed/37020546 http://dx.doi.org/10.3389/fimmu.2023.1128626

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