Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages

Phagocytosis is a key macrophage function, but how phagocytosis shapes tumor-associated macrophage (TAM) phenotypes and heterogeneity in solid tumors remains unclear. Here, we utilized both syngeneic and novel autochthonous lung tumor models in which neoplastic cells express the fluorophore tdTomato...

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Detalles Bibliográficos
Autores principales: Gonzalez, Michael A., Lu, Daniel R., Yousefi, Maryam, Kroll, Ashley, Lo, Chen Hao, Briseño, Carlos G., Watson, J. E. Vivienne, Novitskiy, Sergey, Arias, Vanessa, Zhou, Hong, Plata Stapper, Andres, Tsai, Min K., Ashkin, Emily L., Murray, Christopher W., Li, Chi-Ming, Winslow, Monte M., Tarbell, Kristin V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10067971/
https://www.ncbi.nlm.nih.gov/pubmed/36995340
http://dx.doi.org/10.1084/jem.20221472

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