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Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays

BACKGROUND: Aggregation of α-synuclein (α-syn) is a prominent feature of Parkinson’s disease (PD) and other synucleinopathies. Currently, α-syn seed amplification assays (SAAs) using cerebrospinal fluid (CSF) represent the most promising diagnostic tools for synucleinopathies. However, CSF itself co...

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Detalles Bibliográficos
Autores principales:	Bellomo, Giovanni, Paciotti, Silvia, Concha-Marambio, Luis, Rizzo, Domenico, Wojdaƚa, Anna Lidia, Chiasserini, Davide, Gatticchi, Leonardo, Cerofolini, Linda, Giuntini, Stefano, De Luca, Chiara Maria Giulia, Ma, Yihua, Farris, Carly M., Pieraccini, Giuseppe, Bologna, Sara, Filidei, Marta, Ravera, Enrico, Lelli, Moreno, Moda, Fabio, Fragai, Marco, Parnetti, Lucilla, Luchinat, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068178/ https://www.ncbi.nlm.nih.gov/pubmed/37005644 http://dx.doi.org/10.1186/s13024-023-00613-8

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