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New insights into the function of Interleukin-25 in disease pathogenesis

Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-1...

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Autores principales: Yuan, Qingfang, Peng, Na, Xiao, Fan, Shi, Xiaofei, Zhu, Bo, Rui, Ke, Tian, Jie, Lu, Liwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068183/
https://www.ncbi.nlm.nih.gov/pubmed/37005677
http://dx.doi.org/10.1186/s40364-023-00474-9
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author Yuan, Qingfang
Peng, Na
Xiao, Fan
Shi, Xiaofei
Zhu, Bo
Rui, Ke
Tian, Jie
Lu, Liwei
author_facet Yuan, Qingfang
Peng, Na
Xiao, Fan
Shi, Xiaofei
Zhu, Bo
Rui, Ke
Tian, Jie
Lu, Liwei
author_sort Yuan, Qingfang
collection PubMed
description Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-17RA and IL-17RB receptors. The binding of IL-25 to IL-17RA/IL-17RB complex not only initiates and maintains type 2 immunity but also regulates other immune cells (e.g., macrophages and mast cells) via various signaling pathways. It has been well-documented that IL-25 is critically involved in the development of allergic disorders (e.g., asthma). However, the roles of IL-25 in the pathogenesis of other diseases and the underlying mechanisms are still unclear. This review presents current evidence on the roles of IL-25 in cancers, allergic disorders, and autoimmune diseases. Moreover, we discuss the unanswered key questions underlying IL-25-mediated disease pathology, which will provide new insights into the targeted therapy of this cytokine in clinical treatment.
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spelling pubmed-100681832023-04-04 New insights into the function of Interleukin-25 in disease pathogenesis Yuan, Qingfang Peng, Na Xiao, Fan Shi, Xiaofei Zhu, Bo Rui, Ke Tian, Jie Lu, Liwei Biomark Res Review Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-17RA and IL-17RB receptors. The binding of IL-25 to IL-17RA/IL-17RB complex not only initiates and maintains type 2 immunity but also regulates other immune cells (e.g., macrophages and mast cells) via various signaling pathways. It has been well-documented that IL-25 is critically involved in the development of allergic disorders (e.g., asthma). However, the roles of IL-25 in the pathogenesis of other diseases and the underlying mechanisms are still unclear. This review presents current evidence on the roles of IL-25 in cancers, allergic disorders, and autoimmune diseases. Moreover, we discuss the unanswered key questions underlying IL-25-mediated disease pathology, which will provide new insights into the targeted therapy of this cytokine in clinical treatment. BioMed Central 2023-04-01 /pmc/articles/PMC10068183/ /pubmed/37005677 http://dx.doi.org/10.1186/s40364-023-00474-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yuan, Qingfang
Peng, Na
Xiao, Fan
Shi, Xiaofei
Zhu, Bo
Rui, Ke
Tian, Jie
Lu, Liwei
New insights into the function of Interleukin-25 in disease pathogenesis
title New insights into the function of Interleukin-25 in disease pathogenesis
title_full New insights into the function of Interleukin-25 in disease pathogenesis
title_fullStr New insights into the function of Interleukin-25 in disease pathogenesis
title_full_unstemmed New insights into the function of Interleukin-25 in disease pathogenesis
title_short New insights into the function of Interleukin-25 in disease pathogenesis
title_sort new insights into the function of interleukin-25 in disease pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068183/
https://www.ncbi.nlm.nih.gov/pubmed/37005677
http://dx.doi.org/10.1186/s40364-023-00474-9
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