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A novel HDAC6 inhibitor, CKD-504, is effective in treating preclinical models of huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disorder, of which pathogenesis is caused by a polyglutamine expansion in the amino-terminus of huntingtin gene that resulted in the aggregation of mutant HTT proteins. HD is characterized by progressive motor dysfunction, cognitive impairment and neu...

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Detalles Bibliográficos
Autores principales:	Li, Endan, Choi, Jiwoo, Sim, Hye-Ri, Kim, Jiyeon, Jun, Jae Hyun, Kyung, Jangbeen, Ha, Nina, Kim, Semi, Ryu, Keun Ho, Chung, Seung Soo, Kim, Hyun Sook, Lee, Sungsu, Seol, Wongi, Song, Jihwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068348/ https://www.ncbi.nlm.nih.gov/pubmed/36593104 http://dx.doi.org/10.5483/BMBRep.2022-0157

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