Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis

BACKGROUND: There are limited data describing clinical flucytosine pharmacokinetics (PK). The variability of flucytosine partitioning into the CNS is not known. We described the interindividual variability in flucytosine PK in patients with HIV-associated cryptococcal meningoencephalitis. In additio...

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Detalles Bibliográficos
Autores principales: Stott, Katharine E, Ahmadu, Ajisa, Kajanga, Cheusisime, Moyo, Melanie, Gondwe, Ebbie, Chimang’anga, Wezzie, Chasweka, Madalitso, Unsworth, Jennifer, Jimenez-Valverde, Ana, Jagota, Bhavana, Shah, Reya V, Lawrence, David S, Lalloo, David G, Harrison, Tom, Jarvis, Joseph N, Hope, William, Mwandumba, Henry C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068416/
https://www.ncbi.nlm.nih.gov/pubmed/36857467
http://dx.doi.org/10.1093/jac/dkad038

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