Plasma protein binding of ceftriaxone in critically ill patients: can we predict unbound fractions?

BACKGROUND: Standard antibiotic dosing is not suitable for critically ill patients, due to altered pharmacokinetics (PK) in these patients. Knowledge of protein binding is important for optimizing antibiotic exposure because only the unbound fraction is pharmacologically active. If unbound fractions...

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Detalles Bibliográficos
Autores principales: Ewoldt, Tim M J, Bahmany, Soma, Abdulla, Alan, Muller, Anouk E, Endeman, Henrik, Koch, Birgit C P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068419/
https://www.ncbi.nlm.nih.gov/pubmed/36849582
http://dx.doi.org/10.1093/jac/dkad046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068419/
https://www.ncbi.nlm.nih.gov/pubmed/36849582
http://dx.doi.org/10.1093/jac/dkad046

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