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Plasma protein binding of ceftriaxone in critically ill patients: can we predict unbound fractions?
BACKGROUND: Standard antibiotic dosing is not suitable for critically ill patients, due to altered pharmacokinetics (PK) in these patients. Knowledge of protein binding is important for optimizing antibiotic exposure because only the unbound fraction is pharmacologically active. If unbound fractions...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068419/ https://www.ncbi.nlm.nih.gov/pubmed/36849582 http://dx.doi.org/10.1093/jac/dkad046 |