Tissue-Resident Memory T Cells in Pancreatic Ductal Adenocarcinoma Coexpress PD-1 and TIGIT and Functional Inhibition Is Reversible by Dual Antibody Blockade

Pancreatic ductal adenocarcinoma (PDAC) has a poor clinical outlook. Responses to immune checkpoint blockade are suboptimal and a much more detailed understanding of the tumor immune microenvironment is needed if this situation is to be improved. Here, we characterized tumor-infiltrating T-cell popu...

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Detalles Bibliográficos
Autores principales: Pearce, Hayden, Croft, Wayne, Nicol, Samantha M., Margielewska-Davies, Sandra, Powell, Richard, Cornall, Richard, Davis, Simon J., Marcon, Francesca, Pugh, Matthew R., Fennell, Éanna, Powell-Brett, Sarah, Mahon, Brinder S., Brown, Rachel M., Middleton, Gary, Roberts, Keith, Moss, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068448/
https://www.ncbi.nlm.nih.gov/pubmed/36689623
http://dx.doi.org/10.1158/2326-6066.CIR-22-0121

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