LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD), and activating mutations frequently co-occur with loss-of-function mutations in TP53 or STK11/LKB1. However, mutation of all three genes is rarely observed in hLUAD, even though engineered comutation is highly aggres...

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Detalles Bibliográficos
Autores principales: Stein, Benjamin D., Ferrarone, John R., Gardner, Eric E., Chang, Jae Won, Wu, David, Hollstein, Pablo E., Liang, Roger J., Yuan, Min, Chen, Qiuying, Coukos, John S., Sindelar, Miriam, Ngo, Bryan, Gross, Steven S., Shaw, Reuben J., Zhang, Chen, Asara, John M., Moellering, Raymond E., Varmus, Harold, Cantley, Lewis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068449/
https://www.ncbi.nlm.nih.gov/pubmed/36715544
http://dx.doi.org/10.1158/2159-8290.CD-22-0805

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