Cargando…

Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating

The success of chimeric antigen receptor (CAR) T cells targeting B-cell malignancies propelled the field of synthetic immunology and raised hopes to treat solid tumors in a similar fashion. Antigen escape and the paucity of tumor-restricted CAR targets are recognized challenges to fulfilling this pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hamieh, Mohamad, Mansilla-Soto, Jorge, Rivière, Isabelle, Sadelain, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068450/ https://www.ncbi.nlm.nih.gov/pubmed/36961206 http://dx.doi.org/10.1158/2159-8290.CD-23-0101

Ejemplares similares

S104: DIFFERENTIAL TARGET PROFILES AND EFFICACY OF ADCLEC.SYN1 AND CD33-CARS IN HUMANIZED AML MODELS
por: Haubner, Sascha, et al.
Publicado: (2023)

How do CARs work?: Early insights from recent clinical studies targeting CD19
por: Davila, Marco L., et al.
Publicado: (2012)

G-quadruplexes for luminescent sensing and logic gates
por: He, Hong-Zhang, et al.
Publicado: (2013)

Specific and safe targeting of glioblastoma using switchable and logic-gated RevCAR T cells
por: Saleh, Haidy A., et al.
Publicado: (2023)

Driving CARs to new places: locally produced BCMA CAR T cells to treat multiple myeloma
por: Sjöstrand, Maria, et al.
Publicado: (2023)

Antigen-Triggered Logic-Gating of DNA Nanodevices
por: Engelen, Wouter, et al.
Publicado: (2021)

Controllable DNA nanodevices regulated by logic gates for multi-stimulus recognition
por: Hu, Yingxin, et al.
Publicado: (2023)

Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
por: Kloss, Christopher C, et al.
Publicado: (2012)

Senolytic CAR T cells reverse senescence-associated pathologies
por: Amor, Corina, et al.
Publicado: (2020)

Chirality logic gates
por: Zhang, Yi, et al.
Publicado: (2022)

An MHC-restricted antibody-based chimeric antigen receptor requires TCR-like affinity to maintain antigen specificity
por: Maus, Marcela V, et al.
Publicado: (2017)

Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function
por: Salzer, Benjamin, et al.
Publicado: (2020)

The Amplified DNA Logic Gates Based on Aptamer–Receptor Recognition for Cell Detection and Bioimaging
por: Wang, Yajing, et al.
Publicado: (2023)

Logical gates in actin monomer
por: Adamatzky, Andrew
Publicado: (2017)

Implementation of cascade logic gates and majority logic gate on a simple and universal molecular platform
por: Gao, Jinting, et al.
Publicado: (2017)

Logic-gated antibody pairs that selectively act on cells co-expressing two antigens
por: Oostindie, Simone C., et al.
Publicado: (2022)

Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility
por: Celichowski, Piotr, et al.
Publicado: (2023)

Logic Gates Based on DNA Aptamers
por: Andrianova, Mariia, et al.
Publicado: (2020)

NanoThermoMechanical AND and OR Logic Gates
por: Hamed, Ahmed, et al.
Publicado: (2020)

Carbon Dots-Based Logic Gates
por: Pawar, Shweta, et al.
Publicado: (2021)

Advances in Applications of Molecular Logic Gates
por: Liu, Lijun, et al.
Publicado: (2021)

Nematic bits and universal logic gates
por: Kos, Žiga, et al.
Publicado: (2022)

Catalyst-based biomolecular logic gates
por: Winston, Dennis S., et al.
Publicado: (2022)

Logical gates in ensembles of proteinoid microspheres
por: Mougkogiannis, Panagiotis, et al.
Publicado: (2023)

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
por: Zhong, Wenhe, et al.
Publicado: (2017)

From logic to logic programming
por: Doets, Kees
Publicado: (1994)

A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation
por: Chen, Mengqi, et al.
Publicado: (2022)

wpLogicNet: logic gate and structure inference in gene regulatory networks
por: Malekpour, Seyed Amir, et al.
Publicado: (2023)

Tuning the performance of CAR T cell immunotherapies
por: Richardson, Noah H., et al.
Publicado: (2019)

Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
por: Chen, Jian, et al.
Publicado: (2023)

Digital systems: from logic gates to processors
por: Deschamps, Jean-Pierre, et al.
Publicado: (2017)

Cascaded logic gates in nanophotonic plasmon networks
por: Wei, Hong, et al.
Publicado: (2011)

Excitonic AND Logic Gates on DNA Brick Nanobreadboards
por: Cannon, Brittany L., et al.
Publicado: (2015)

Broadband reconfigurable logic gates in phonon waveguides
por: Hatanaka, D., et al.
Publicado: (2017)

Additively manufacturable micro-mechanical logic gates
por: Song, Yuanping, et al.
Publicado: (2019)

Terahertz Spoof Surface Plasmonic Logic Gates
por: Yuan, Mingrui, et al.
Publicado: (2020)

Binary-phase acoustic passive logic gates
por: Wang, Yin, et al.
Publicado: (2019)

Implementing Logic Gates for Safer Immunotherapy of Cancer
por: Savanur, Mohammed Azharuddin, et al.
Publicado: (2021)

Gate-controlled electron quantum interference logic
por: Weinbub, Josef, et al.
Publicado: (2022)

Untethered Soft Microrobots with Adaptive Logic Gates
por: Wang, Zichao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dp5l7dtb7hm8uhf3t03ouauanl