Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma

PURPOSE: Cisplatin (CDDP)-based chemotherapy is a first-line treatment for patients with advanced head and neck squamous cell carcinomas (HNSCC), despite a high rate of treatment failures, acquired resistance, and subsequent aggressive behavior. The purpose of this study was to study the mechanism o...

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Detalles Bibliográficos
Autores principales: Osman, Abdullah A., Arslan, Emre, Bartels, Mason, Michikawa, Chieko, Lindemann, Antje, Tomczak, Katarzyna, Yu, Wangjie, Sandulache, Vlad, Ma, Wencai, Shen, Li, Wang, Jing, Singh, Anand K., Frederick, Mitchell J., Spencer, Nakia D., Kovacs, Jeffery, Heffernan, Timothy, Symmans, William F., Rai, Kunal, Myers, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068451/
https://www.ncbi.nlm.nih.gov/pubmed/36689560
http://dx.doi.org/10.1158/1078-0432.CCR-22-2747

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