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Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells

BACKGROUND: Traditional herbal medicines usually contain electron shuttle (ES)-like structures compounds which are potential candidates for antiviral compounds selection. Houttuynia cordata is applied as a biomaterial to decipher its potential applications in bioenergy extraction in microbial fuel c...

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Autores principales: Lin, Chia-Kai, Chen, Bor-Yann, Ting, Jasmine U., Rogio, Kristian Gil G., Tsai, Po-Wei, Liu, Yung-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. on behalf of Taiwan Institute of Chemical Engineers. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068517/
https://www.ncbi.nlm.nih.gov/pubmed/37051508
http://dx.doi.org/10.1016/j.jtice.2023.104838
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author Lin, Chia-Kai
Chen, Bor-Yann
Ting, Jasmine U.
Rogio, Kristian Gil G.
Tsai, Po-Wei
Liu, Yung-Chuan
author_facet Lin, Chia-Kai
Chen, Bor-Yann
Ting, Jasmine U.
Rogio, Kristian Gil G.
Tsai, Po-Wei
Liu, Yung-Chuan
author_sort Lin, Chia-Kai
collection PubMed
description BACKGROUND: Traditional herbal medicines usually contain electron shuttle (ES)-like structures compounds which are potential candidates for antiviral compounds selection. Houttuynia cordata is applied as a biomaterial to decipher its potential applications in bioenergy extraction in microbial fuel cells (MFCs) and anti-COVID-19 via molecular docking evaluation. METHODS: H. cordata leaves extracts by water and 60% ethanol solvent were analyzed for total polyphenols, antioxidant activity, cyclic voltammetry (CV), and MFCs. The bioactive compounds of H. cordata leaves extracts were assayed via LC/MS analysis. Identification of the marker substances for potential antiviral activity using a molecular docking model was provided. SIGNIFICANT FINDINGS: 60% ethanol extract exhibits the highest total polyphenols and antioxidant activity compared with water extracts. Bioenergy extraction in MFCs showed that 60% ethanol extracts could give 1.76-fold more power generation compared to the blank. Flavonoids and their sugar-to-glycan ratios increased after CV scanning and they are expected to be effective ES substances. Quercitrin, from the H. cordata extract that shares an ES-like structure, was found to exhibit strong binding affinities towards ACE2 and RdRp. This indicated the potential of H. cordata leaves as a promising antiviral herb.
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spelling pubmed-100685172023-04-03 Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells Lin, Chia-Kai Chen, Bor-Yann Ting, Jasmine U. Rogio, Kristian Gil G. Tsai, Po-Wei Liu, Yung-Chuan J Taiwan Inst Chem Eng Energy and Environmental Science and Technology BACKGROUND: Traditional herbal medicines usually contain electron shuttle (ES)-like structures compounds which are potential candidates for antiviral compounds selection. Houttuynia cordata is applied as a biomaterial to decipher its potential applications in bioenergy extraction in microbial fuel cells (MFCs) and anti-COVID-19 via molecular docking evaluation. METHODS: H. cordata leaves extracts by water and 60% ethanol solvent were analyzed for total polyphenols, antioxidant activity, cyclic voltammetry (CV), and MFCs. The bioactive compounds of H. cordata leaves extracts were assayed via LC/MS analysis. Identification of the marker substances for potential antiviral activity using a molecular docking model was provided. SIGNIFICANT FINDINGS: 60% ethanol extract exhibits the highest total polyphenols and antioxidant activity compared with water extracts. Bioenergy extraction in MFCs showed that 60% ethanol extracts could give 1.76-fold more power generation compared to the blank. Flavonoids and their sugar-to-glycan ratios increased after CV scanning and they are expected to be effective ES substances. Quercitrin, from the H. cordata extract that shares an ES-like structure, was found to exhibit strong binding affinities towards ACE2 and RdRp. This indicated the potential of H. cordata leaves as a promising antiviral herb. Published by Elsevier B.V. on behalf of Taiwan Institute of Chemical Engineers. 2023-04 2023-04-03 /pmc/articles/PMC10068517/ /pubmed/37051508 http://dx.doi.org/10.1016/j.jtice.2023.104838 Text en © 2023 Published by Elsevier B.V. on behalf of Taiwan Institute of Chemical Engineers. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Energy and Environmental Science and Technology
Lin, Chia-Kai
Chen, Bor-Yann
Ting, Jasmine U.
Rogio, Kristian Gil G.
Tsai, Po-Wei
Liu, Yung-Chuan
Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells
title Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells
title_full Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells
title_fullStr Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells
title_full_unstemmed Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells
title_short Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells
title_sort deciphering houttuynia cordata extract as electron shuttles with anti-covid-19 activity and its performance in microbial fuel cells
topic Energy and Environmental Science and Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068517/
https://www.ncbi.nlm.nih.gov/pubmed/37051508
http://dx.doi.org/10.1016/j.jtice.2023.104838
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