Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination

Despite the approval of vaccines, monoclonal antibodies and restrictions during the pandemic, the demand for new efficacious and safe antivirals is compelling to boost the therapeutic arsenal against the COVID-19. The viral 3-chymotrypsin-like protease (3CL(pro)) is an essential enzyme for replicati...

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Detalles Bibliográficos
Autores principales: Stefanelli, Irina, Corona, Angela, Cerchia, Carmen, Cassese, Emilia, Improta, Salvatore, Costanzi, Elisa, Pelliccia, Sveva, Morasso, Stefano, Esposito, Francesca, Paulis, Annalaura, Scognamiglio, Sante, Di Leva, Francesco Saverio, Storici, Paola, Brindisi, Margherita, Tramontano, Enzo, Cannalire, Rolando, Summa, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068823/
https://www.ncbi.nlm.nih.gov/pubmed/37043904
http://dx.doi.org/10.1016/j.ejmech.2023.115311

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