Cargando…

Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions

Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffening of the large elastic arteries, each of which is an indepe...

Descripción completa

Detalles Bibliográficos
Autores principales: Murray, Kevin O., Mahoney, Sophia A., Venkatasubramanian, Ravinandan, Seals, Douglas R., Clayton, Zachary S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068966/
https://www.ncbi.nlm.nih.gov/pubmed/36731386
http://dx.doi.org/10.1016/j.exger.2023.112105
_version_ 1785018765722779648
author Murray, Kevin O.
Mahoney, Sophia A.
Venkatasubramanian, Ravinandan
Seals, Douglas R.
Clayton, Zachary S.
author_facet Murray, Kevin O.
Mahoney, Sophia A.
Venkatasubramanian, Ravinandan
Seals, Douglas R.
Clayton, Zachary S.
author_sort Murray, Kevin O.
collection PubMed
description Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffening of the large elastic arteries, each of which is an independent predictor of CVD. These processes are largely mediated by an excess production of reactive oxygen species (ROS) and an increase in chronic, low-grade inflammation that ultimately leads to a reduction in bioavailability of the vasodilatory molecule nitric oxide. Additionally, there are other fundamental aging mechanisms that may contribute to excessive ROS and inflammation termed the “hallmarks of aging”) these additional mechanisms of arterial dysfunction may represent therapeutic targets for improving CV health with aging. Aerobic exercise is the most well-known and effective intervention to prevent and treat the effects of aging on CV dysfunction. However, the majority of mid-life and older (ML/O) adults do not meet recommended exercise guidelines due to traditional barriers to aerobic exercise, such as reduced leisure time, motivation, or access to fitness facilities. Therefore, it is a biomedical research priority to develop and implement time- and resource-efficient alternative strategies to aerobic exercise to reduce the burden of CVD in ML/O adults. Alternative strategies that mimic or are inspired by aerobic exercise, that target pathways specific to the fundamental mechanisms of aging, represent a promising approach to accomplish this goal.
format Online
Article
Text
id pubmed-10068966
institution National Center for Biotechnology Information
language English
publishDate 2023
record_format MEDLINE/PubMed
spelling pubmed-100689662023-04-03 Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions Murray, Kevin O. Mahoney, Sophia A. Venkatasubramanian, Ravinandan Seals, Douglas R. Clayton, Zachary S. Exp Gerontol Article Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is characterized by impaired vascular endothelial function and stiffening of the large elastic arteries, each of which is an independent predictor of CVD. These processes are largely mediated by an excess production of reactive oxygen species (ROS) and an increase in chronic, low-grade inflammation that ultimately leads to a reduction in bioavailability of the vasodilatory molecule nitric oxide. Additionally, there are other fundamental aging mechanisms that may contribute to excessive ROS and inflammation termed the “hallmarks of aging”) these additional mechanisms of arterial dysfunction may represent therapeutic targets for improving CV health with aging. Aerobic exercise is the most well-known and effective intervention to prevent and treat the effects of aging on CV dysfunction. However, the majority of mid-life and older (ML/O) adults do not meet recommended exercise guidelines due to traditional barriers to aerobic exercise, such as reduced leisure time, motivation, or access to fitness facilities. Therefore, it is a biomedical research priority to develop and implement time- and resource-efficient alternative strategies to aerobic exercise to reduce the burden of CVD in ML/O adults. Alternative strategies that mimic or are inspired by aerobic exercise, that target pathways specific to the fundamental mechanisms of aging, represent a promising approach to accomplish this goal. 2023-03 2023-01-31 /pmc/articles/PMC10068966/ /pubmed/36731386 http://dx.doi.org/10.1016/j.exger.2023.112105 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Murray, Kevin O.
Mahoney, Sophia A.
Venkatasubramanian, Ravinandan
Seals, Douglas R.
Clayton, Zachary S.
Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions
title Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions
title_full Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions
title_fullStr Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions
title_full_unstemmed Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions
title_short Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions
title_sort aging, aerobic exercise, and cardiovascular health: barriers, alternative strategies and future directions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068966/
https://www.ncbi.nlm.nih.gov/pubmed/36731386
http://dx.doi.org/10.1016/j.exger.2023.112105
work_keys_str_mv AT murraykevino agingaerobicexerciseandcardiovascularhealthbarriersalternativestrategiesandfuturedirections
AT mahoneysophiaa agingaerobicexerciseandcardiovascularhealthbarriersalternativestrategiesandfuturedirections
AT venkatasubramanianravinandan agingaerobicexerciseandcardiovascularhealthbarriersalternativestrategiesandfuturedirections
AT sealsdouglasr agingaerobicexerciseandcardiovascularhealthbarriersalternativestrategiesandfuturedirections
AT claytonzacharys agingaerobicexerciseandcardiovascularhealthbarriersalternativestrategiesandfuturedirections