Cargando…
Association Between Transforming Growth Factor-β1 Polymorphisms and Ischemic Stroke Susceptibility: A Meta-Analysis
Epidemiological studies have suggested a potential relationship between the transforming growth factor-β1 (TGF-β1) gene and ischemic stroke (IS) risk; however, the current results are inconsistent. Therefore, we performed this meta-analysis to assess the precise association between TGF-β1 polymorphi...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068975/ https://www.ncbi.nlm.nih.gov/pubmed/36998191 http://dx.doi.org/10.1177/10760296231166666 |
_version_ | 1785018767785328640 |
---|---|
author | Peng, Xiao-Qin Cheng, Fan Zhou, Lan |
author_facet | Peng, Xiao-Qin Cheng, Fan Zhou, Lan |
author_sort | Peng, Xiao-Qin |
collection | PubMed |
description | Epidemiological studies have suggested a potential relationship between the transforming growth factor-β1 (TGF-β1) gene and ischemic stroke (IS) risk; however, the current results are inconsistent. Therefore, we performed this meta-analysis to assess the precise association between TGF-β1 polymorphisms and IS risk. Online databases were searched for themes related to TGF-β1 polymorphisms and ARE risk. Quantitative calculations of odds ratios (ORs) and confidence intervals (CIs) were performed using 5 genetic models of each variant locus. Heterogeneity tests, cumulative analyses, sensitivity analyses, and publication bias were conducted to examine statistical power. Moreover, changes in the secondary structure and minimum free energy (MFE) were explored using in silico analysis. Nineteen case-control studies were included in our meta-analysis on rs1800468 G>A, rs1800469 C>T, and rs1800470 T>C polymorphisms and IS risk. Overall, only a marginal association was found between the rs1800469 C>T polymorphism and IS risk (T vs C: OR = 1.12, 95%CI = 1.00-1.46, P = .05, I(2) = 77.0%). Otherwise, no significant association was observed between the rs1800468 G>A and rs1800470 T>C polymorphisms and IS risk in general and stratified analyses. Moreover, no significant changes in secondary structure and MFE were found in any of the 3 polymorphic loci. Current evidence cautiously suggests that TGF-β1 polymorphisms are not associated with IS susceptibility. |
format | Online Article Text |
id | pubmed-10068975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-100689752023-04-04 Association Between Transforming Growth Factor-β1 Polymorphisms and Ischemic Stroke Susceptibility: A Meta-Analysis Peng, Xiao-Qin Cheng, Fan Zhou, Lan Clin Appl Thromb Hemost Original Manuscript Epidemiological studies have suggested a potential relationship between the transforming growth factor-β1 (TGF-β1) gene and ischemic stroke (IS) risk; however, the current results are inconsistent. Therefore, we performed this meta-analysis to assess the precise association between TGF-β1 polymorphisms and IS risk. Online databases were searched for themes related to TGF-β1 polymorphisms and ARE risk. Quantitative calculations of odds ratios (ORs) and confidence intervals (CIs) were performed using 5 genetic models of each variant locus. Heterogeneity tests, cumulative analyses, sensitivity analyses, and publication bias were conducted to examine statistical power. Moreover, changes in the secondary structure and minimum free energy (MFE) were explored using in silico analysis. Nineteen case-control studies were included in our meta-analysis on rs1800468 G>A, rs1800469 C>T, and rs1800470 T>C polymorphisms and IS risk. Overall, only a marginal association was found between the rs1800469 C>T polymorphism and IS risk (T vs C: OR = 1.12, 95%CI = 1.00-1.46, P = .05, I(2) = 77.0%). Otherwise, no significant association was observed between the rs1800468 G>A and rs1800470 T>C polymorphisms and IS risk in general and stratified analyses. Moreover, no significant changes in secondary structure and MFE were found in any of the 3 polymorphic loci. Current evidence cautiously suggests that TGF-β1 polymorphisms are not associated with IS susceptibility. SAGE Publications 2023-03-30 /pmc/articles/PMC10068975/ /pubmed/36998191 http://dx.doi.org/10.1177/10760296231166666 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Manuscript Peng, Xiao-Qin Cheng, Fan Zhou, Lan Association Between Transforming Growth Factor-β1 Polymorphisms and Ischemic Stroke Susceptibility: A Meta-Analysis |
title | Association Between Transforming Growth Factor-β1 Polymorphisms and
Ischemic Stroke Susceptibility: A Meta-Analysis |
title_full | Association Between Transforming Growth Factor-β1 Polymorphisms and
Ischemic Stroke Susceptibility: A Meta-Analysis |
title_fullStr | Association Between Transforming Growth Factor-β1 Polymorphisms and
Ischemic Stroke Susceptibility: A Meta-Analysis |
title_full_unstemmed | Association Between Transforming Growth Factor-β1 Polymorphisms and
Ischemic Stroke Susceptibility: A Meta-Analysis |
title_short | Association Between Transforming Growth Factor-β1 Polymorphisms and
Ischemic Stroke Susceptibility: A Meta-Analysis |
title_sort | association between transforming growth factor-β1 polymorphisms and
ischemic stroke susceptibility: a meta-analysis |
topic | Original Manuscript |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068975/ https://www.ncbi.nlm.nih.gov/pubmed/36998191 http://dx.doi.org/10.1177/10760296231166666 |
work_keys_str_mv | AT pengxiaoqin associationbetweentransforminggrowthfactorb1polymorphismsandischemicstrokesusceptibilityametaanalysis AT chengfan associationbetweentransforminggrowthfactorb1polymorphismsandischemicstrokesusceptibilityametaanalysis AT zhoulan associationbetweentransforminggrowthfactorb1polymorphismsandischemicstrokesusceptibilityametaanalysis |