Elevated Angiotensin-II Levels Contribute to the Pathogenesis of Open-Angle Glaucoma Via Inducing the Expression of Fibrosis-Related Genes in Trabecular Meshwork Cells Through a ROS/NOX4/SMAD3 Axis

Glaucoma including primary open-angle glaucoma (POAG) results from elevations in intraocular pressure (IOP). An eye-localized renin-angiotensin system (RAS) has been implicated in IOP regulation, although its mechanism of action and contribution to glaucoma is poorly understood. Here, we detected si...

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Detalles Bibliográficos
Autores principales: Li, Haijun, Cui, Huiling, Ren, Jing, Wang, Di, Zhao, Rumeng, Zhu, Shichao, Liu, Siqing, Liu, Xiaohui, Tian, Shuai, Zhang, Yuanyuan, Zhao, Panpan, Li, Peng, Thorne, Rick F., Duan, Shichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068978/
https://www.ncbi.nlm.nih.gov/pubmed/36999649
http://dx.doi.org/10.1177/09636897231162526

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