Cargando…

hMSH2 coordinated with the expression of E2F1 promotes platinum response in epithelial ovarian cancer

OBJECTIVE: To explore underlying mechanisms that regulate hMSH2 expression and drug susceptibility in epithelial ovarian cancer (EOC). METHODS: Using data from the Cancer Genome Atlas (TCGA) we used bioinformatical analysis to predict transcription factors (TFs) that potentially regulate hMSH2. RT-q...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Xiao-qian, Zhang, Bao-ying, Hua, Tian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2023
Materias:	Pre-Clinical Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10068988/ https://www.ncbi.nlm.nih.gov/pubmed/36994850 http://dx.doi.org/10.1177/03000605231163780

Ejemplares similares

Hypermethylation of mismatch repair gene hMSH2 associates with platinum-resistant disease in epithelial ovarian cancer
por: Tian, Hua, et al.
Publicado: (2019)

hMSH2 and GTBP expression in advanced stage epithelial ovarian cancer
por: Ercoli, A, et al.
Publicado: (1999)

Loss or Somatic Mutations of hMSH2 Occur in Hereditary Nonpolyposis Colorectal Cancers with hMSH2 Germline Mutations
por: Lu, Shi‐Long, et al.
Publicado: (1996)

MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human Diseases
por: Clark, Nicole, et al.
Publicado: (2013)

Population carrier frequency of hMSH2 and hMLH1 mutations
por: Dunlop, M G, et al.
Publicado: (2000)

Expression of hMLH1 and hMSH2 proteins in ameloblastomas and tooth germs
por: Bologna-Molina, Ronell, et al.
Publicado: (2018)

DNA Damage Induced MutS Homologue hMSH4 Acetylation
por: Chu, Yen-Lin, et al.
Publicado: (2013)

MutS homologue hMSH4: interaction with eIF3f and a role in NHEJ-mediated DSB repair
por: Chu, Yen-Lin, et al.
Publicado: (2013)

Mapping of the methylation pattern of the hMSH2 promoter in colon cancer, using bisulfite genomic sequencing
por: Zhang, Hua, et al.
Publicado: (2006)

Prevalence of Pathological Germline Mutations of hMLH1 and hMSH2 Genes in Colorectal Cancer
por: Li, Dandan, et al.
Publicado: (2013)

A Mononucleotide Markers Panel to Identify hMLH1/hMSH2 Germline Mutations
por: Pedroni, M., et al.
Publicado: (2007)

Frameshift Mutations of the hMSH6 Gene in Human Leukemia Cell Lines
por: Hosoya, Noriko, et al.
Publicado: (1998)

Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer
por: Palicio, M, et al.
Publicado: (2000)

The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor α
por: Wada-Hiraike, O, et al.
Publicado: (2005)

hMSH2 is the most commonly mutated MMR gene in a cohort of Greek HNPCC patients
por: Apessos, A, et al.
Publicado: (2005)

Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus
por: Pimenta, Flávio Juliano Garcia Santos, et al.
Publicado: (2004)

Expression of human DNA mismatch-repair protein, hMSH2, in patients with oral lichen planus
por: LI, HAO-BO, et al.
Publicado: (2015)

MutS homologue hMSH5: role in cisplatin-induced DNA damage response
por: Tompkins, Joshua D, et al.
Publicado: (2012)

hMSH5 Regulates NHEJ and Averts Excessive Nucleotide Alterations at Repair Joints
por: Al-Soodani, Aneesa T., et al.
Publicado: (2022)

Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer
por: Kassem, H Sh, et al.
Publicado: (2001)

Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis
por: Sarmento, Dmitry José de Santana, et al.
Publicado: (2016)

MutS Homologue hMSH5: Recombinational DSB Repair and Non-Synonymous Polymorphic Variants
por: Wu, Xiling, et al.
Publicado: (2013)

Novel DNA Variants and Mutation Frequencies of hMLH1 and hMSH2 Genes in Colorectal Cancer in the Northeast China Population
por: Hu, Fulan, et al.
Publicado: (2013)

The association between genetic variants in hMLH1 and hMSH2 and the development of sporadic colorectal cancer in the Danish population
por: Christensen, Lise Lotte, et al.
Publicado: (2008)

Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.
por: Tomlinson, I. P., et al.
Publicado: (1996)

Mismatch Repair Protein hMLH1, but not hMSH2, Enhances Estrogen-Induced Apoptosis of Colon Cancer Cells
por: Jin, Peng, et al.
Publicado: (2017)

Mutational Analysis of Mismatch Repair Genes, hMLH1 and hMSH2, in Sporadic Endometrial Carcinomas with Microsatellite Instability
por: Kobayashi, Kanji, et al.
Publicado: (1996)

Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in Early Gastric Cancer (EGC)
por: Zhu, Xueru, et al.
Publicado: (2017)

hMSH5 is a nucleocytoplasmic shuttling protein whose stability depends on its subcellular localization
por: Lahaye, François, et al.
Publicado: (2010)

Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells
por: Campregher, C, et al.
Publicado: (2008)

A missense mutation in both hMSH2 andAPC in an Ashkenazi Jewish HNPCC kindred: implications for clinical screening
por: YUAN, ZHI QIANG, et al.
Publicado: (1999)

Frequent loss of heterozygosity at the DNA mismatch-repair loci hMLH1 and hMSH3 in sporadic breast cancer
por: Benachenhou, N, et al.
Publicado: (1999)

Frameshift Mutations and a Length Polymorphism in the hMSH3 Gene and the Spectrum of Microsatellite Instability in Sporadic Colon Cancer
por: Orimo, Hideo, et al.
Publicado: (1999)

Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1
por: Duan, Jianxiu, et al.
Publicado: (2021)

Oxidative Stress Induces Nuclear-to-Cytosol Shift of hMSH3, a Potential Mechanism for EMAST in Colorectal Cancer Cells
por: Tseng-Rogenski, Stephanie S., et al.
Publicado: (2012)

miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2
por: Ye, Ling, et al.
Publicado: (2017)

Gly322Asp and Asn127Ser single nucleotide polymorphisms (SNPs) of hMSH2 mismatch repair gene and the risk of triple-negative breast cancer in Polish women
por: Smolarz, Beata, et al.
Publicado: (2014)

Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposis
por: Bai, Haibo, et al.
Publicado: (2005)

Surgery in platinum-resistant recurrent epithelial ovarian carcinoma
por: Zhao, Ling-Qin, et al.
Publicado: (2022)

Prerecognition Diffusion Mechanism of Human DNA Mismatch Repair Proteins along DNA: Msh2-Msh3 versus Msh2-Msh6
por: Pal, Arumay, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3ood5rjf4r6v2pnrj3a8i7d1l7