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Pre-treatment bronchoscopic evaluation in a case of relapsing polychondrits
BACKGROUND: Relapsing polychondritis (RP) is a chronic and recurrent inflammatory disease of the cartilage tissues in the body. The cause of RP is unknown, and since it is a rare disease with symptoms that affect multiple organs, diagnosis is often delayed. CASE PRESENTATION: A 62-year-old woman wit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069111/ https://www.ncbi.nlm.nih.gov/pubmed/37013530 http://dx.doi.org/10.1186/s12890-023-02400-z |
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author | Kumagai, Kosumi Tsuruoka, Hajime Morikawa, Kei Handa, Hiroshi Mineshita, Masamichi |
author_facet | Kumagai, Kosumi Tsuruoka, Hajime Morikawa, Kei Handa, Hiroshi Mineshita, Masamichi |
author_sort | Kumagai, Kosumi |
collection | PubMed |
description | BACKGROUND: Relapsing polychondritis (RP) is a chronic and recurrent inflammatory disease of the cartilage tissues in the body. The cause of RP is unknown, and since it is a rare disease with symptoms that affect multiple organs, diagnosis is often delayed. CASE PRESENTATION: A 62-year-old woman with no smoking history visited our institution complaining of fever, cough, and dyspnoea. Chest CT showed a stenosis from the left main bronchus to the left lower lobe branch. Bronchoscopy visualised intense erythema and oedema at the left main bronchus, with airway narrowing. Biopsy of the ear revealed degenerative vitreous cartilage and fibrous connective tissue with a mild inflammatory cell infiltrate. She was subsequently diagnosed with RP and administered systemic corticosteroid therapy. Her symptoms improved rapidly, and post-treatment bronchoscopy revealed that although mild erythema of the airway epithelium remained, oedema markedly improved, and the airway stenosis was resolved. CONCLUSIONS: We report a case where pre-treatment bronchoscopy was able to visually confirm RP at the acute stage. Since RP is difficult to diagnose, severe airway narrowing can occur prior to diagnosis. Therefore, to determine the stage of the disease, it is helpful to perform bronchoscopic observation before treatment. However, bronchoscopic observation before treatment should be performed by experienced bronchoscopists due to the risk of airway obstruction. |
format | Online Article Text |
id | pubmed-10069111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-100691112023-04-04 Pre-treatment bronchoscopic evaluation in a case of relapsing polychondrits Kumagai, Kosumi Tsuruoka, Hajime Morikawa, Kei Handa, Hiroshi Mineshita, Masamichi BMC Pulm Med Case Report BACKGROUND: Relapsing polychondritis (RP) is a chronic and recurrent inflammatory disease of the cartilage tissues in the body. The cause of RP is unknown, and since it is a rare disease with symptoms that affect multiple organs, diagnosis is often delayed. CASE PRESENTATION: A 62-year-old woman with no smoking history visited our institution complaining of fever, cough, and dyspnoea. Chest CT showed a stenosis from the left main bronchus to the left lower lobe branch. Bronchoscopy visualised intense erythema and oedema at the left main bronchus, with airway narrowing. Biopsy of the ear revealed degenerative vitreous cartilage and fibrous connective tissue with a mild inflammatory cell infiltrate. She was subsequently diagnosed with RP and administered systemic corticosteroid therapy. Her symptoms improved rapidly, and post-treatment bronchoscopy revealed that although mild erythema of the airway epithelium remained, oedema markedly improved, and the airway stenosis was resolved. CONCLUSIONS: We report a case where pre-treatment bronchoscopy was able to visually confirm RP at the acute stage. Since RP is difficult to diagnose, severe airway narrowing can occur prior to diagnosis. Therefore, to determine the stage of the disease, it is helpful to perform bronchoscopic observation before treatment. However, bronchoscopic observation before treatment should be performed by experienced bronchoscopists due to the risk of airway obstruction. BioMed Central 2023-04-03 /pmc/articles/PMC10069111/ /pubmed/37013530 http://dx.doi.org/10.1186/s12890-023-02400-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Kumagai, Kosumi Tsuruoka, Hajime Morikawa, Kei Handa, Hiroshi Mineshita, Masamichi Pre-treatment bronchoscopic evaluation in a case of relapsing polychondrits |
title | Pre-treatment bronchoscopic evaluation in a case of relapsing polychondrits |
title_full | Pre-treatment bronchoscopic evaluation in a case of relapsing polychondrits |
title_fullStr | Pre-treatment bronchoscopic evaluation in a case of relapsing polychondrits |
title_full_unstemmed | Pre-treatment bronchoscopic evaluation in a case of relapsing polychondrits |
title_short | Pre-treatment bronchoscopic evaluation in a case of relapsing polychondrits |
title_sort | pre-treatment bronchoscopic evaluation in a case of relapsing polychondrits |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069111/ https://www.ncbi.nlm.nih.gov/pubmed/37013530 http://dx.doi.org/10.1186/s12890-023-02400-z |
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