Cargando…

Spatial-dependent suppressive aftereffect produced by a sound in the rat’s inferior colliculus is partially dependent on local inhibition

In a natural acoustic environment, a preceding sound can suppress the perception of a succeeding sound which can lead to auditory phenomena such as forward masking and the precedence effect. The degree of suppression is dependent on the relationship between the sounds in sound quality, timing, and l...

Descripción completa

Detalles Bibliográficos
Autores principales: Asim, Syed Anam, Tran, Sarah, Reynolds, Nicholas, Sauve, Olivia, Zhang, Huiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069703/
https://www.ncbi.nlm.nih.gov/pubmed/37021140
http://dx.doi.org/10.3389/fnins.2023.1130892
_version_ 1785018901555314688
author Asim, Syed Anam
Tran, Sarah
Reynolds, Nicholas
Sauve, Olivia
Zhang, Huiming
author_facet Asim, Syed Anam
Tran, Sarah
Reynolds, Nicholas
Sauve, Olivia
Zhang, Huiming
author_sort Asim, Syed Anam
collection PubMed
description In a natural acoustic environment, a preceding sound can suppress the perception of a succeeding sound which can lead to auditory phenomena such as forward masking and the precedence effect. The degree of suppression is dependent on the relationship between the sounds in sound quality, timing, and location. Correlates of such phenomena exist in sound-elicited activities of neurons in hearing-related brain structures. The present study recorded responses to pairs of leading-trailing sounds from ensembles of neurons in the rat’s inferior colliculus. Results indicated that a leading sound produced a suppressive aftereffect on the response to a trailing sound when the two sounds were colocalized at the ear contralateral to the site of recording (i.e., the ear that drives excitatory inputs to the inferior colliculus). The degree of suppression was reduced when the time gap between the two sounds was increased or when the leading sound was relocated to an azimuth at or close to the ipsilateral ear. Local blockage of the type-A γ-aminobutyric acid receptor partially reduced the suppressive aftereffect when a leading sound was at the contralateral ear but not at the ipsilateral ear. Local blockage of the glycine receptor partially reduced the suppressive aftereffect regardless of the location of the leading sound. Results suggest that a sound-elicited suppressive aftereffect in the inferior colliculus is partly dependent on local interaction between excitatory and inhibitory inputs which likely involves those from brainstem structures such as the superior paraolivary nucleus. These results are important for understanding neural mechanisms underlying hearing in a multiple-sound environment.
format Online
Article
Text
id pubmed-10069703
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100697032023-04-04 Spatial-dependent suppressive aftereffect produced by a sound in the rat’s inferior colliculus is partially dependent on local inhibition Asim, Syed Anam Tran, Sarah Reynolds, Nicholas Sauve, Olivia Zhang, Huiming Front Neurosci Neuroscience In a natural acoustic environment, a preceding sound can suppress the perception of a succeeding sound which can lead to auditory phenomena such as forward masking and the precedence effect. The degree of suppression is dependent on the relationship between the sounds in sound quality, timing, and location. Correlates of such phenomena exist in sound-elicited activities of neurons in hearing-related brain structures. The present study recorded responses to pairs of leading-trailing sounds from ensembles of neurons in the rat’s inferior colliculus. Results indicated that a leading sound produced a suppressive aftereffect on the response to a trailing sound when the two sounds were colocalized at the ear contralateral to the site of recording (i.e., the ear that drives excitatory inputs to the inferior colliculus). The degree of suppression was reduced when the time gap between the two sounds was increased or when the leading sound was relocated to an azimuth at or close to the ipsilateral ear. Local blockage of the type-A γ-aminobutyric acid receptor partially reduced the suppressive aftereffect when a leading sound was at the contralateral ear but not at the ipsilateral ear. Local blockage of the glycine receptor partially reduced the suppressive aftereffect regardless of the location of the leading sound. Results suggest that a sound-elicited suppressive aftereffect in the inferior colliculus is partly dependent on local interaction between excitatory and inhibitory inputs which likely involves those from brainstem structures such as the superior paraolivary nucleus. These results are important for understanding neural mechanisms underlying hearing in a multiple-sound environment. Frontiers Media S.A. 2023-03-20 /pmc/articles/PMC10069703/ /pubmed/37021140 http://dx.doi.org/10.3389/fnins.2023.1130892 Text en Copyright © 2023 Asim, Tran, Reynolds, Sauve and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Asim, Syed Anam
Tran, Sarah
Reynolds, Nicholas
Sauve, Olivia
Zhang, Huiming
Spatial-dependent suppressive aftereffect produced by a sound in the rat’s inferior colliculus is partially dependent on local inhibition
title Spatial-dependent suppressive aftereffect produced by a sound in the rat’s inferior colliculus is partially dependent on local inhibition
title_full Spatial-dependent suppressive aftereffect produced by a sound in the rat’s inferior colliculus is partially dependent on local inhibition
title_fullStr Spatial-dependent suppressive aftereffect produced by a sound in the rat’s inferior colliculus is partially dependent on local inhibition
title_full_unstemmed Spatial-dependent suppressive aftereffect produced by a sound in the rat’s inferior colliculus is partially dependent on local inhibition
title_short Spatial-dependent suppressive aftereffect produced by a sound in the rat’s inferior colliculus is partially dependent on local inhibition
title_sort spatial-dependent suppressive aftereffect produced by a sound in the rat’s inferior colliculus is partially dependent on local inhibition
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069703/
https://www.ncbi.nlm.nih.gov/pubmed/37021140
http://dx.doi.org/10.3389/fnins.2023.1130892
work_keys_str_mv AT asimsyedanam spatialdependentsuppressiveaftereffectproducedbyasoundintheratsinferiorcolliculusispartiallydependentonlocalinhibition
AT transarah spatialdependentsuppressiveaftereffectproducedbyasoundintheratsinferiorcolliculusispartiallydependentonlocalinhibition
AT reynoldsnicholas spatialdependentsuppressiveaftereffectproducedbyasoundintheratsinferiorcolliculusispartiallydependentonlocalinhibition
AT sauveolivia spatialdependentsuppressiveaftereffectproducedbyasoundintheratsinferiorcolliculusispartiallydependentonlocalinhibition
AT zhanghuiming spatialdependentsuppressiveaftereffectproducedbyasoundintheratsinferiorcolliculusispartiallydependentonlocalinhibition