Cargando…

Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex

Gamma oscillations are believed to underlie cognitive processes by shaping the formation of transient neuronal partnerships on a millisecond scale. These oscillations are coupled to the phase of breathing cycles in several brain areas, possibly reflecting local computations driven by sensory inputs...

Descripción completa

Detalles Bibliográficos
Autores principales: Gonzalez, Joaquin, Torterolo, Pablo, Tort, Adriano BL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069865/
https://www.ncbi.nlm.nih.gov/pubmed/36806332
http://dx.doi.org/10.7554/eLife.83044
_version_ 1785018932426440704
author Gonzalez, Joaquin
Torterolo, Pablo
Tort, Adriano BL
author_facet Gonzalez, Joaquin
Torterolo, Pablo
Tort, Adriano BL
author_sort Gonzalez, Joaquin
collection PubMed
description Gamma oscillations are believed to underlie cognitive processes by shaping the formation of transient neuronal partnerships on a millisecond scale. These oscillations are coupled to the phase of breathing cycles in several brain areas, possibly reflecting local computations driven by sensory inputs sampled at each breath. Here, we investigated the mechanisms and functions of gamma oscillations in the piriform (olfactory) cortex of awake mice to understand their dependence on breathing and how they relate to local spiking activity. Mechanistically, we find that respiration drives gamma oscillations in the piriform cortex, which correlate with local feedback inhibition and result from recurrent connections between local excitatory and inhibitory neuronal populations. Moreover, respiration-driven gamma oscillations are triggered by the activation of mitral/tufted cells in the olfactory bulb and are abolished during ketamine/xylazine anesthesia. Functionally, we demonstrate that they locally segregate neuronal assemblies through a winner-take-all computation leading to sparse odor coding during each breathing cycle. Our results shed new light on the mechanisms of gamma oscillations, bridging computation, cognition, and physiology.
format Online
Article
Text
id pubmed-10069865
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-100698652023-04-04 Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex Gonzalez, Joaquin Torterolo, Pablo Tort, Adriano BL eLife Neuroscience Gamma oscillations are believed to underlie cognitive processes by shaping the formation of transient neuronal partnerships on a millisecond scale. These oscillations are coupled to the phase of breathing cycles in several brain areas, possibly reflecting local computations driven by sensory inputs sampled at each breath. Here, we investigated the mechanisms and functions of gamma oscillations in the piriform (olfactory) cortex of awake mice to understand their dependence on breathing and how they relate to local spiking activity. Mechanistically, we find that respiration drives gamma oscillations in the piriform cortex, which correlate with local feedback inhibition and result from recurrent connections between local excitatory and inhibitory neuronal populations. Moreover, respiration-driven gamma oscillations are triggered by the activation of mitral/tufted cells in the olfactory bulb and are abolished during ketamine/xylazine anesthesia. Functionally, we demonstrate that they locally segregate neuronal assemblies through a winner-take-all computation leading to sparse odor coding during each breathing cycle. Our results shed new light on the mechanisms of gamma oscillations, bridging computation, cognition, and physiology. eLife Sciences Publications, Ltd 2023-02-20 /pmc/articles/PMC10069865/ /pubmed/36806332 http://dx.doi.org/10.7554/eLife.83044 Text en © 2023, Gonzalez et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Gonzalez, Joaquin
Torterolo, Pablo
Tort, Adriano BL
Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex
title Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex
title_full Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex
title_fullStr Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex
title_full_unstemmed Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex
title_short Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex
title_sort mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069865/
https://www.ncbi.nlm.nih.gov/pubmed/36806332
http://dx.doi.org/10.7554/eLife.83044
work_keys_str_mv AT gonzalezjoaquin mechanismsandfunctionsofrespirationdrivengammaoscillationsintheprimaryolfactorycortex
AT torterolopablo mechanismsandfunctionsofrespirationdrivengammaoscillationsintheprimaryolfactorycortex
AT tortadrianobl mechanismsandfunctionsofrespirationdrivengammaoscillationsintheprimaryolfactorycortex