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Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth
Precise organization of growing structures is a fundamental process in developmental biology. In plants, radial growth is mediated by the cambium, a stem cell niche continuously producing wood (xylem) and bast (phloem) in a strictly bidirectional manner. While this process contributes large parts to...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069871/ https://www.ncbi.nlm.nih.gov/pubmed/36897801 http://dx.doi.org/10.7554/eLife.66627 |
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author | Lebovka, Ivan Hay Mele, Bruno Liu, Xiaomin Zakieva, Alexandra Schlamp, Theresa Gursanscky, Nial Rau Merks, Roeland MH Großeholz, Ruth Greb, Thomas |
author_facet | Lebovka, Ivan Hay Mele, Bruno Liu, Xiaomin Zakieva, Alexandra Schlamp, Theresa Gursanscky, Nial Rau Merks, Roeland MH Großeholz, Ruth Greb, Thomas |
author_sort | Lebovka, Ivan |
collection | PubMed |
description | Precise organization of growing structures is a fundamental process in developmental biology. In plants, radial growth is mediated by the cambium, a stem cell niche continuously producing wood (xylem) and bast (phloem) in a strictly bidirectional manner. While this process contributes large parts to terrestrial biomass, cambium dynamics eludes direct experimental access due to obstacles in live-cell imaging. Here, we present a cell-based computational model visualizing cambium activity and integrating the function of central cambium regulators. Performing iterative comparisons of plant and model anatomies, we conclude that the receptor-like kinase PXY and its ligand CLE41 are part of a minimal framework sufficient for instructing tissue organization. By integrating tissue-specific cell wall stiffness values, we moreover probe the influence of physical constraints on tissue geometry. Our model highlights the role of intercellular communication within the cambium and shows that a limited number of factors are sufficient to create radial growth by bidirectional tissue production. |
format | Online Article Text |
id | pubmed-10069871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-100698712023-04-04 Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth Lebovka, Ivan Hay Mele, Bruno Liu, Xiaomin Zakieva, Alexandra Schlamp, Theresa Gursanscky, Nial Rau Merks, Roeland MH Großeholz, Ruth Greb, Thomas eLife Plant Biology Precise organization of growing structures is a fundamental process in developmental biology. In plants, radial growth is mediated by the cambium, a stem cell niche continuously producing wood (xylem) and bast (phloem) in a strictly bidirectional manner. While this process contributes large parts to terrestrial biomass, cambium dynamics eludes direct experimental access due to obstacles in live-cell imaging. Here, we present a cell-based computational model visualizing cambium activity and integrating the function of central cambium regulators. Performing iterative comparisons of plant and model anatomies, we conclude that the receptor-like kinase PXY and its ligand CLE41 are part of a minimal framework sufficient for instructing tissue organization. By integrating tissue-specific cell wall stiffness values, we moreover probe the influence of physical constraints on tissue geometry. Our model highlights the role of intercellular communication within the cambium and shows that a limited number of factors are sufficient to create radial growth by bidirectional tissue production. eLife Sciences Publications, Ltd 2023-03-10 /pmc/articles/PMC10069871/ /pubmed/36897801 http://dx.doi.org/10.7554/eLife.66627 Text en © 2023, Lebovka et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Plant Biology Lebovka, Ivan Hay Mele, Bruno Liu, Xiaomin Zakieva, Alexandra Schlamp, Theresa Gursanscky, Nial Rau Merks, Roeland MH Großeholz, Ruth Greb, Thomas Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth |
title | Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth |
title_full | Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth |
title_fullStr | Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth |
title_full_unstemmed | Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth |
title_short | Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth |
title_sort | computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth |
topic | Plant Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10069871/ https://www.ncbi.nlm.nih.gov/pubmed/36897801 http://dx.doi.org/10.7554/eLife.66627 |
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