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JAK-STAT activation contributes to cytotoxic T cell–mediated basal cell death in human chronic lung allograft dysfunction

Chronic lung allograft dysfunction (CLAD) is the leading cause of death in lung transplant recipients. CLAD is characterized clinically by a persistent decline in pulmonary function and histologically by the development of airway-centered fibrosis known as bronchiolitis obliterans. There are no appr...

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Detalles Bibliográficos
Autores principales: Khatri, Aaditya, Todd, Jamie L., Kelly, Fran L., Nagler, Andrew, Ji, Zhicheng, Jain, Vaibhav, Gregory, Simon G., Weinhold, Kent J., Palmer, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070100/
https://www.ncbi.nlm.nih.gov/pubmed/36946463
http://dx.doi.org/10.1172/jci.insight.167082