EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation

Arrhythmogenic cardiomyopathy (AC) is a familial heart disease partly caused by impaired desmosome turnover. Thus, stabilization of desmosome integrity may provide new treatment options. Desmosomes, apart from cellular cohesion, provide the structural framework of a signaling hub. Here, we investiga...

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Detalles Bibliográficos
Autores principales: Shoykhet, Maria, Dervishi, Orsela, Menauer, Philipp, Hiermaier, Matthias, Moztarzadeh, Sina, Osterloh, Colin, Ludwig, Ralf J., Williams, Tatjana, Gerull, Brenda, Kääb, Stefan, Clauss, Sebastian, Schüttler, Dominik, Waschke, Jens, Yeruva, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070108/
https://www.ncbi.nlm.nih.gov/pubmed/36795511
http://dx.doi.org/10.1172/jci.insight.163763

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