Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology

The shift in cancer therapy from broadly cytotoxic agents toward “personalized” treatments that target specific alterations in each patient's tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly. Novel multiplexed antibody-based imaging technologies can...

Descripción completa

Detalles Bibliográficos
Autores principales: Pourmaleki, Maryam, Socci, Nicholas D., Hollmann, Travis J., Mellinghoff, Ingo K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
In Focus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070169/
https://www.ncbi.nlm.nih.gov/pubmed/37009699
http://dx.doi.org/10.1158/2159-8290.CD-22-1015
_version_ 1785018971880161280
author Pourmaleki, Maryam
Socci, Nicholas D.
Hollmann, Travis J.
Mellinghoff, Ingo K.
author_facet Pourmaleki, Maryam
Socci, Nicholas D.
Hollmann, Travis J.
Mellinghoff, Ingo K.
author_sort Pourmaleki, Maryam
collection PubMed
description The shift in cancer therapy from broadly cytotoxic agents toward “personalized” treatments that target specific alterations in each patient's tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly. Novel multiplexed antibody-based imaging technologies can measure single-cell expression of over 60 proteins in intact tumor sections and hold promise for clinical oncology.
format Online
Article
Text
id pubmed-10070169
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher American Association for Cancer Research
record_format MEDLINE/PubMed
spelling pubmed-100701692023-04-05 Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology Pourmaleki, Maryam Socci, Nicholas D. Hollmann, Travis J. Mellinghoff, Ingo K. Cancer Discov In Focus The shift in cancer therapy from broadly cytotoxic agents toward “personalized” treatments that target specific alterations in each patient's tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly. Novel multiplexed antibody-based imaging technologies can measure single-cell expression of over 60 proteins in intact tumor sections and hold promise for clinical oncology. American Association for Cancer Research 2023-04-03 2023-04-03 /pmc/articles/PMC10070169/ /pubmed/37009699 http://dx.doi.org/10.1158/2159-8290.CD-22-1015 Text en ©2023 The Authors; Published by the American Association for Cancer Research https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.
spellingShingle In Focus
Pourmaleki, Maryam
Socci, Nicholas D.
Hollmann, Travis J.
Mellinghoff, Ingo K.
Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology
title Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology
title_full Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology
title_fullStr Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology
title_full_unstemmed Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology
title_short Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology
title_sort moving spatially resolved multiplexed protein profiling toward clinical oncology
topic In Focus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070169/
https://www.ncbi.nlm.nih.gov/pubmed/37009699
http://dx.doi.org/10.1158/2159-8290.CD-22-1015
work_keys_str_mv AT pourmalekimaryam movingspatiallyresolvedmultiplexedproteinprofilingtowardclinicaloncology
AT soccinicholasd movingspatiallyresolvedmultiplexedproteinprofilingtowardclinicaloncology
AT hollmanntravisj movingspatiallyresolvedmultiplexedproteinprofilingtowardclinicaloncology
AT mellinghoffingok movingspatiallyresolvedmultiplexedproteinprofilingtowardclinicaloncology

Ejemplares similares