Dynamics of Age- versus Therapy-Related Clonal Hematopoiesis in Long-term Survivors of Pediatric Cancer

We present the first comprehensive investigation of clonal hematopoiesis (CH) in 2,860 long-term survivors of pediatric cancer with a median follow-up time of 23.5 years. Deep sequencing over 39 CH-related genes reveals mutations in 15% of the survivors, significantly higher than the 8.5% in 324 com...

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Detalles Bibliográficos
Autores principales: Hagiwara, Kohei, Natarajan, Sivaraman, Wang, Zhaoming, Zubair, Haseeb, Mulder, Heather L., Dong, Li, Plyler, Emily M., Thimmaiah, Padma, Ma, Xiaotu, Ness, Kristen K., Li, Zhenghong, Mulrooney, Daniel A., Wilson, Carmen L., Yasui, Yutaka, Hudson, Melissa M., Easton, John, Robison, Leslie L., Zhang, Jinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070170/
https://www.ncbi.nlm.nih.gov/pubmed/36751942
http://dx.doi.org/10.1158/2159-8290.CD-22-0956

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