The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of the wild-type (wt) TP53 tumour suppressive functions. Therefore, compounds that can restore wt TP53 functions in mutant TP53 proteins are expected to inhibit the expansio...

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Detalles Bibliográficos
Autores principales: Wang, Zilu, Hu, Huimin, Heitink, Luuk, Rogers, Kelly, You, Yue, Tan, Tao, Suen, Connie Li Wai, Garnham, Alex, Chen, Hao, Lieschke, Elizabeth, Diepstraten, Sarah T., Chang, Catherine, Chen, Tianwei, Moujalled, Diane, Sutherland, Kate, Lessene, Guillaume, Sieber, Oliver M., Visvader, Jane, Kelly, Gemma L., Strasser, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070280/
https://www.ncbi.nlm.nih.gov/pubmed/36739334
http://dx.doi.org/10.1038/s41418-023-01122-3

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