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TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis

TMPRSS6 is a serine protease highly expressed in the liver. Its role in iron regulation was first reported in 2008 when mutations in TMPRSS6 were shown to be the cause of iron-refractory iron deficiency anemia (IRIDA) in humans and in mouse models. TMPRSS6 functions as a negative regulator of the ex...

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Detalles Bibliográficos
Autores principales:	Ganz, Tomas, Nemeth, Elizabeta, Rivella, Stefano, Goldberg, Paul, Dibble, Andrew R., McCaleb, Michael L., Guo, Shuling, Monia, Brett P., Barrett, Terrance D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Healthcare 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070284/ https://www.ncbi.nlm.nih.gov/pubmed/36690839 http://dx.doi.org/10.1007/s12325-022-02421-w

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