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Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs

BH3-mimetic drugs are an anti-cancer therapy that can induce apoptosis in malignant cells by directly binding and inhibiting pro-survival proteins of the BCL-2 family. The BH3-mimetic drug venetoclax, which targets BCL-2, has been approved for the treatment of chronic lymphocytic leukaemia and acute...

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Detalles Bibliográficos
Autores principales:	Diepstraten, Sarah T., Young, Savannah, La Marca, John E., Wang, Zilu, Kluck, Ruth M., Strasser, Andreas, Kelly, Gemma L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070326/ https://www.ncbi.nlm.nih.gov/pubmed/36755070 http://dx.doi.org/10.1038/s41418-023-01117-0

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