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PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functions

The VHL protein (pVHL) functions as a tumor suppressor by regulating the degradation or activation of protein substrates such as HIF1α and Akt. In human cancers harboring wild-type VHL, the aberrant downregulation of pVHL is frequently detected and critically contributes to tumor progression. Howeve...

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Detalles Bibliográficos
Autores principales:	Chen, Jiayi, Li, Mei, Liu, Yeqing, Guan, Tangming, Yang, Xiao, Wen, Yalei, Zhu, Yingjie, Xiao, Zeyu, Shen, Xiangchun, Zhang, Haoxing, Tang, Hui, Liu, Tongzheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070344/ https://www.ncbi.nlm.nih.gov/pubmed/36813923 http://dx.doi.org/10.1038/s41418-023-01128-x

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