Cell differentiation modifies the p53 transcriptional program through a combination of gene silencing and constitutive transactivation

The p53 transcription factor is a master regulator of cellular responses to stress that is commonly inactivated in diverse cancer types. Despite decades of research, the mechanisms by which p53 impedes tumorigenesis across vastly different cellular contexts requires further investigation. The bulk o...

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Detalles Bibliográficos
Autores principales: Tatavosian, Roubina, Donovan, Micah G., Galbraith, Matthew D., Duc, Huy N., Szwarc, Maria M., Joshi, Molishree U., Frieman, Amy, Bilousova, Ganna, Cao, Yingqiong, Smith, Keith P., Song, Kunhua, Rachubinski, Angela L., Andrysik, Zdenek, Espinosa, Joaquin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070495/
https://www.ncbi.nlm.nih.gov/pubmed/36681780
http://dx.doi.org/10.1038/s41418-023-01113-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070495/
https://www.ncbi.nlm.nih.gov/pubmed/36681780
http://dx.doi.org/10.1038/s41418-023-01113-4

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