Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor

HMG-CoA reductase (HMGR), a rate-limiting enzyme of the mevalonate pathway in Gram-positive pathogenic bacteria, is an attractive target for development of novel antibiotics. In this study, we report the crystal structures of HMGR from Enterococcus faecalis (efHMGR) in the apo and liganded forms, hi...

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Detalles Bibliográficos
Autores principales: Bose, Sucharita, Steussy, C. Nicklaus, López-Pérez, Daneli, Schmidt, Tim, Kulathunga, Samadhi C., Seleem, Mohamed N., Lipton, Mark, Mesecar, Andrew D., Rodwell, Victor W., Stauffacher, Cynthia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070635/
https://www.ncbi.nlm.nih.gov/pubmed/37012403
http://dx.doi.org/10.1038/s42003-023-04639-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070635/
https://www.ncbi.nlm.nih.gov/pubmed/37012403
http://dx.doi.org/10.1038/s42003-023-04639-y

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