Cargando…

Epigenetic clocks and female fertility timeline: A new approach to an old issue?

Worldwide increase in life expectancy has boosted research on aging. Overcoming the concept of chronological age, higher attention has been addressed to biological age, which reflects a person’s real health state, and which may be the resulting combination of both intrinsic and environmental factors...

Descripción completa

Detalles Bibliográficos
Autores principales: Li Piani, Letizia, Vigano', Paola, Somigliana, Edgardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070683/
https://www.ncbi.nlm.nih.gov/pubmed/37025178
http://dx.doi.org/10.3389/fcell.2023.1121231
_version_ 1785019045891801088
author Li Piani, Letizia
Vigano', Paola
Somigliana, Edgardo
author_facet Li Piani, Letizia
Vigano', Paola
Somigliana, Edgardo
author_sort Li Piani, Letizia
collection PubMed
description Worldwide increase in life expectancy has boosted research on aging. Overcoming the concept of chronological age, higher attention has been addressed to biological age, which reflects a person’s real health state, and which may be the resulting combination of both intrinsic and environmental factors. As epigenetics may exert a pivotal role in the biological aging, epigenetic clocks were developed. They are based on mathematical models aimed at identifying DNA methylation patterns that can define the biological age and that can be adopted for different clinical scopes (i.e., estimation of the risks of developing age-related disorders or predicting lifespan). Recently, epigenetic clocks have gained a peculiar attention in the fertility research field, in particular in the female counterpart. The insight into the possible relations between epigenetic aging and women’s infertility might glean additional information about certain conditions that are still not completely understood. Moreover, they could disclose significant implications for health promotion programs in infertile women. Of relevance here is that the impact of biological age and epigenetics may not be limited to fertility status but could translate into pregnancy issues. Indeed, epigenetic alterations of the mother may transfer into the offspring, and pregnancy itself as well as related complications could contribute to epigenetic modifications in both the mother and newborn. However, even if the growing interest has culminated in the conspicuous production of studies on these topics, a global overview and the availability of validated instruments for diagnosis is still missing. The present narrative review aims to explore the possible bonds between epigenetic aging and fertility timeline. In the “infertility” section, we will discuss the advances on epigenetic clocks focusing on the different tissues examined (endometrium, peripheral blood, ovaries). In the “pregnancy” section, we will discuss the results obtained from placenta, umbilical cord and peripheral blood. The possible role of epigenetic aging on infertility mechanisms and pregnancy outcomes represents a question that may configure epigenetic clock as a bond between two apparently opposite worlds: infertility and pregnancy.
format Online
Article
Text
id pubmed-10070683
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100706832023-04-05 Epigenetic clocks and female fertility timeline: A new approach to an old issue? Li Piani, Letizia Vigano', Paola Somigliana, Edgardo Front Cell Dev Biol Cell and Developmental Biology Worldwide increase in life expectancy has boosted research on aging. Overcoming the concept of chronological age, higher attention has been addressed to biological age, which reflects a person’s real health state, and which may be the resulting combination of both intrinsic and environmental factors. As epigenetics may exert a pivotal role in the biological aging, epigenetic clocks were developed. They are based on mathematical models aimed at identifying DNA methylation patterns that can define the biological age and that can be adopted for different clinical scopes (i.e., estimation of the risks of developing age-related disorders or predicting lifespan). Recently, epigenetic clocks have gained a peculiar attention in the fertility research field, in particular in the female counterpart. The insight into the possible relations between epigenetic aging and women’s infertility might glean additional information about certain conditions that are still not completely understood. Moreover, they could disclose significant implications for health promotion programs in infertile women. Of relevance here is that the impact of biological age and epigenetics may not be limited to fertility status but could translate into pregnancy issues. Indeed, epigenetic alterations of the mother may transfer into the offspring, and pregnancy itself as well as related complications could contribute to epigenetic modifications in both the mother and newborn. However, even if the growing interest has culminated in the conspicuous production of studies on these topics, a global overview and the availability of validated instruments for diagnosis is still missing. The present narrative review aims to explore the possible bonds between epigenetic aging and fertility timeline. In the “infertility” section, we will discuss the advances on epigenetic clocks focusing on the different tissues examined (endometrium, peripheral blood, ovaries). In the “pregnancy” section, we will discuss the results obtained from placenta, umbilical cord and peripheral blood. The possible role of epigenetic aging on infertility mechanisms and pregnancy outcomes represents a question that may configure epigenetic clock as a bond between two apparently opposite worlds: infertility and pregnancy. Frontiers Media S.A. 2023-03-21 /pmc/articles/PMC10070683/ /pubmed/37025178 http://dx.doi.org/10.3389/fcell.2023.1121231 Text en Copyright © 2023 Li Piani, Vigano' and Somigliana. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Li Piani, Letizia
Vigano', Paola
Somigliana, Edgardo
Epigenetic clocks and female fertility timeline: A new approach to an old issue?
title Epigenetic clocks and female fertility timeline: A new approach to an old issue?
title_full Epigenetic clocks and female fertility timeline: A new approach to an old issue?
title_fullStr Epigenetic clocks and female fertility timeline: A new approach to an old issue?
title_full_unstemmed Epigenetic clocks and female fertility timeline: A new approach to an old issue?
title_short Epigenetic clocks and female fertility timeline: A new approach to an old issue?
title_sort epigenetic clocks and female fertility timeline: a new approach to an old issue?
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070683/
https://www.ncbi.nlm.nih.gov/pubmed/37025178
http://dx.doi.org/10.3389/fcell.2023.1121231
work_keys_str_mv AT lipianiletizia epigeneticclocksandfemalefertilitytimelineanewapproachtoanoldissue
AT viganopaola epigeneticclocksandfemalefertilitytimelineanewapproachtoanoldissue
AT somiglianaedgardo epigeneticclocksandfemalefertilitytimelineanewapproachtoanoldissue