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A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages

BACKGROUND: A recombinant fusion protein combining the adjuvant and TLR5-ligand flagellin with the major birch pollen allergen Bet v 1 (rFlaA:Betv1) has been suggested to prevent the manifestation of birch allergy. Noteworthy, rFlaA:Betv1 induced both pro- and anti-inflammatory responses which were...

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Detalles Bibliográficos
Autores principales:	Lin, Yen-Ju, Jamin, Annette, Wolfheimer, Sonja, Fiedler, Anna, Junker, Ann-Christine, Goretzki, Alexandra, Scheurer, Stephan, Schülke, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070734/ https://www.ncbi.nlm.nih.gov/pubmed/37026001 http://dx.doi.org/10.3389/fimmu.2023.1136669

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