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Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study
INTRODUCTION: The study aimed to demonstrate the risk factors for fractures and to develop prediction models for major osteoporotic and hip fractures in osteopenic patients using the nationwide cohort study in South Korea. METHODS: The study was a retrospective nationwide study using the national sc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070847/ https://www.ncbi.nlm.nih.gov/pubmed/37025406 http://dx.doi.org/10.3389/fendo.2023.1085252 |
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author | Kong, Sung Hye Jo, Ae Jeong Park, Chan Mi Park, Kyun Ik Yun, Ji Eun Kim, Jung Hee |
author_facet | Kong, Sung Hye Jo, Ae Jeong Park, Chan Mi Park, Kyun Ik Yun, Ji Eun Kim, Jung Hee |
author_sort | Kong, Sung Hye |
collection | PubMed |
description | INTRODUCTION: The study aimed to demonstrate the risk factors for fractures and to develop prediction models for major osteoporotic and hip fractures in osteopenic patients using the nationwide cohort study in South Korea. METHODS: The study was a retrospective nationwide study using the national screening program for transitional ages from the National Health Insurance Services database in Korea from 2008 to 2019. Primary outcomes were incident fracture events of major osteoporotic and hip fractures. Major osteoporotic and hip fracture events were defined as diagnostic and procedural codes. Patients were followed until the fragility fractures, death, or 2019, whichever came first. RESULTS: All participants were 66-year-old females, with a mean body mass index was 25.0 ± 3.1 kg/m(2). During a median follow-up of 10.5 years, 26.9% and 6.7% of participants experienced major osteoporotic and hip fractures. In multivariate analysis, a history of fracture, chronic airway disease, falls, diabetes mellitus and cerebrovascular diseases were significant risk factors for major osteoporotic (hazard ratio [HR] 2.35 for a history of fracture; 1.17 for chronic airway disease; 1.10 for falls; 1.12 for diabetes mellitus; 1.11 for cerebrovascular disease) and hip fractures (HR 1.75 for a history of fracture; 1.54 for diabetes mellitus; 1.27 for cerebrovascular disease; 1.17 for fall; 1.15 for chronic airway disease). The performances of the prediction models were area under the receiver operating curve of 0.73 and 0.75 for major osteoporotic and hip fractures. CONCLUSION: The study presented prediction models of major osteoporotic and hip fractures for osteopenia patients using simple clinical features. |
format | Online Article Text |
id | pubmed-10070847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100708472023-04-05 Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study Kong, Sung Hye Jo, Ae Jeong Park, Chan Mi Park, Kyun Ik Yun, Ji Eun Kim, Jung Hee Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: The study aimed to demonstrate the risk factors for fractures and to develop prediction models for major osteoporotic and hip fractures in osteopenic patients using the nationwide cohort study in South Korea. METHODS: The study was a retrospective nationwide study using the national screening program for transitional ages from the National Health Insurance Services database in Korea from 2008 to 2019. Primary outcomes were incident fracture events of major osteoporotic and hip fractures. Major osteoporotic and hip fracture events were defined as diagnostic and procedural codes. Patients were followed until the fragility fractures, death, or 2019, whichever came first. RESULTS: All participants were 66-year-old females, with a mean body mass index was 25.0 ± 3.1 kg/m(2). During a median follow-up of 10.5 years, 26.9% and 6.7% of participants experienced major osteoporotic and hip fractures. In multivariate analysis, a history of fracture, chronic airway disease, falls, diabetes mellitus and cerebrovascular diseases were significant risk factors for major osteoporotic (hazard ratio [HR] 2.35 for a history of fracture; 1.17 for chronic airway disease; 1.10 for falls; 1.12 for diabetes mellitus; 1.11 for cerebrovascular disease) and hip fractures (HR 1.75 for a history of fracture; 1.54 for diabetes mellitus; 1.27 for cerebrovascular disease; 1.17 for fall; 1.15 for chronic airway disease). The performances of the prediction models were area under the receiver operating curve of 0.73 and 0.75 for major osteoporotic and hip fractures. CONCLUSION: The study presented prediction models of major osteoporotic and hip fractures for osteopenia patients using simple clinical features. Frontiers Media S.A. 2023-03-21 /pmc/articles/PMC10070847/ /pubmed/37025406 http://dx.doi.org/10.3389/fendo.2023.1085252 Text en Copyright © 2023 Kong, Jo, Park, Park, Yun and Kim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Kong, Sung Hye Jo, Ae Jeong Park, Chan Mi Park, Kyun Ik Yun, Ji Eun Kim, Jung Hee Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study |
title | Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study |
title_full | Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study |
title_fullStr | Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study |
title_full_unstemmed | Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study |
title_short | Chronic airway disease as a major risk factor for fractures in osteopenic women: Nationwide cohort study |
title_sort | chronic airway disease as a major risk factor for fractures in osteopenic women: nationwide cohort study |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070847/ https://www.ncbi.nlm.nih.gov/pubmed/37025406 http://dx.doi.org/10.3389/fendo.2023.1085252 |
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