Immune-mediated thrombotic thrombocytopenic purpura plasma induces calcium- and IgG-dependent endothelial activation: correlations with disease severity

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is characterized by a severe ADAMTS13 deficiency due to the presence of anti-ADAMTS13 auto-antibodies, with subsequent accumulation of circulating ultra-large von Willebrand factor (VWF) multimers. The role of endothelial cell activation as...

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Detalles Bibliográficos
Autores principales: Tellier, Edwige, Widemann, Agnès, Cauchois, Raphaël, Faccini, Julien, Lagarde, Marie, Brun, Marion, Robert, Philippe, Robert, Stéphane, Bachelier, Richard, Poullin, Pascale, Roose, Elien, Vanhoorelbeke, Karen, Coppo, Paul, Dignat-George, Françoise, Kaplanski, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Platelet Biology & its Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071132/
https://www.ncbi.nlm.nih.gov/pubmed/36453103
http://dx.doi.org/10.3324/haematol.2022.280651

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