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Intrinsic signalling factors associated with cancer cell-cell fusion

Cellular fusion e.g. between cancer cells and normal cells represents a stepwise process that is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer cells are promoted to a pro-fusogenic state as a prerequisite to prepare a fusion process. A pro-fusogenic state req...

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Autores principales: Dittmar, Thomas, Hass, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071245/
https://www.ncbi.nlm.nih.gov/pubmed/37016404
http://dx.doi.org/10.1186/s12964-023-01085-5
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author Dittmar, Thomas
Hass, Ralf
author_facet Dittmar, Thomas
Hass, Ralf
author_sort Dittmar, Thomas
collection PubMed
description Cellular fusion e.g. between cancer cells and normal cells represents a stepwise process that is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer cells are promoted to a pro-fusogenic state as a prerequisite to prepare a fusion process. A pro-fusogenic state requires significant changes including restructure of the cytoskeleton, e.g., by the formation of F-actin. Moreover, distinct plasma membrane lipids such as phosphatidylserine play an important role during cell fusion. In addition, the expression of distinct fusogenic factors such as syncytins and corresponding receptors are of fundamental importance to enable cellular mergers. Subsequent hybrid formation and fusion are followed by a post-hybrid selection process. Fusion among normal cells is important and often required during organismal development. Cancer cells fusion appears more rarely and is associated with the generation of new cancer hybrid cell populations. These cancer hybrid cells contribute to an elevated tumour plasticity by altered metastatic behaviour, changes in therapeutic and apoptotic responses, and even in the formation of cancer stem/ initiating cells. While many parts within this multi-step cascade are still poorly understood, this review article predominantly focusses on the intracellular necessities for fusion among cancer cells or with other cell populations of the tumour microenvironment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01085-5.
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spelling pubmed-100712452023-04-04 Intrinsic signalling factors associated with cancer cell-cell fusion Dittmar, Thomas Hass, Ralf Cell Commun Signal Review Cellular fusion e.g. between cancer cells and normal cells represents a stepwise process that is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer cells are promoted to a pro-fusogenic state as a prerequisite to prepare a fusion process. A pro-fusogenic state requires significant changes including restructure of the cytoskeleton, e.g., by the formation of F-actin. Moreover, distinct plasma membrane lipids such as phosphatidylserine play an important role during cell fusion. In addition, the expression of distinct fusogenic factors such as syncytins and corresponding receptors are of fundamental importance to enable cellular mergers. Subsequent hybrid formation and fusion are followed by a post-hybrid selection process. Fusion among normal cells is important and often required during organismal development. Cancer cells fusion appears more rarely and is associated with the generation of new cancer hybrid cell populations. These cancer hybrid cells contribute to an elevated tumour plasticity by altered metastatic behaviour, changes in therapeutic and apoptotic responses, and even in the formation of cancer stem/ initiating cells. While many parts within this multi-step cascade are still poorly understood, this review article predominantly focusses on the intracellular necessities for fusion among cancer cells or with other cell populations of the tumour microenvironment. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01085-5. BioMed Central 2023-04-04 /pmc/articles/PMC10071245/ /pubmed/37016404 http://dx.doi.org/10.1186/s12964-023-01085-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Dittmar, Thomas
Hass, Ralf
Intrinsic signalling factors associated with cancer cell-cell fusion
title Intrinsic signalling factors associated with cancer cell-cell fusion
title_full Intrinsic signalling factors associated with cancer cell-cell fusion
title_fullStr Intrinsic signalling factors associated with cancer cell-cell fusion
title_full_unstemmed Intrinsic signalling factors associated with cancer cell-cell fusion
title_short Intrinsic signalling factors associated with cancer cell-cell fusion
title_sort intrinsic signalling factors associated with cancer cell-cell fusion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071245/
https://www.ncbi.nlm.nih.gov/pubmed/37016404
http://dx.doi.org/10.1186/s12964-023-01085-5
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