The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

Cytoplasmic dynein-driven movement of chromosomes during prophase I of mammalian meiosis is essential for synapsis and genetic exchange. Dynein connects to chromosome telomeres via KASH5 and SUN1 or SUN2, which together span the nuclear envelope. Here, we show that KASH5 promotes dynein motility in...

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Detalles Bibliográficos
Autores principales: Garner, Kirsten E.L., Salter, Anna, Lau, Clinton K., Gurusaran, Manickam, Villemant, Cécile M., Granger, Elizabeth P., McNee, Gavin, Woodman, Philip G., Davies, Owen R., Burke, Brian E., Allan, Victoria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071310/
https://www.ncbi.nlm.nih.gov/pubmed/36946995
http://dx.doi.org/10.1083/jcb.202204042

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