Preparation and Application of an Inexpensive α-Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis

[Image: see text] α-Formylglycine (fGly) is a rare residue located in the active site of sulfatases and serves as a precursor to pharmaceutically relevant motifs. The installation of fGly motifs into peptides is currently challenging due to degradation under the acidic and nucleophile-rich condition...

Descripción completa

Detalles Bibliográficos
Autores principales: Yates, Nicholas D. J., Warnes, Matthew E., Breetveld, Reuben, Spicer, Christopher D., Signoret, Nathalie, Fascione, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071478/
https://www.ncbi.nlm.nih.gov/pubmed/36662590
http://dx.doi.org/10.1021/acs.orglett.2c04059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071478/
https://www.ncbi.nlm.nih.gov/pubmed/36662590
http://dx.doi.org/10.1021/acs.orglett.2c04059

Ejemplares similares