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Copper-Catalyzed Borylation of Styrenes by 1,8-Diaminonaphthalene-Protected Diboronic Acid
[Image: see text] We report a concise synthesis of 1,8-diaminonaphthalene-protected diboronic acid (B(2)(dan)(2)), which is a promising borylating agent. B(2)(dan)(2) is a bench-stable compound, and it could be utilized for Cu-catalyzed borylation of styrene derivatives. The reaction proceeded in a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071482/ https://www.ncbi.nlm.nih.gov/pubmed/36947669 http://dx.doi.org/10.1021/acs.orglett.3c00451 |
| Sumario: | [Image: see text] We report a concise synthesis of 1,8-diaminonaphthalene-protected diboronic acid (B(2)(dan)(2)), which is a promising borylating agent. B(2)(dan)(2) is a bench-stable compound, and it could be utilized for Cu-catalyzed borylation of styrene derivatives. The reaction proceeded in a highly selective manner, and the products were isolated in up to 97% yields. Mechanistic studies revealed that a borate species would be a key intermediate for the borylation reaction. |
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