A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer

BACKGROUND: Molecular profiling of the tumour immune microenvironment (TIME) has enabled the rational choice of immunotherapies in some adult cancers. In contrast, the TIME of paediatric cancers is relatively unexplored. We speculated that a more refined appreciation of the TIME in childhood cancers...

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Detalles Bibliográficos
Autores principales: Mayoh, Chelsea, Gifford, Andrew J., Terry, Rachael, Lau, Loretta M. S., Wong, Marie, Rao, Padmashree, Shai-Hee, Tyler, Saletta, Federica, Khuong-Quang, Dong-Anh, Qin, Vicky, Mateos, Marion K., Meyran, Deborah, Miller, Katherine E., Yuksel, Aysen, Mould, Emily V. A., Bowen-James, Rachel, Govender, Dinisha, Senapati, Akanksha, Zhukova, Nataliya, Omer, Natacha, Dholaria, Hetal, Alvaro, Frank, Tapp, Heather, Diamond, Yonatan, Pozza, Luciano Dalla, Moore, Andrew S., Nicholls, Wayne, Gottardo, Nicholas G., McCowage, Geoffrey, Hansford, Jordan R., Khaw, Seong-Lin, Wood, Paul J., Catchpoole, Daniel, Cottrell, Catherine E., Mardis, Elaine R., Marshall, Glenn M., Tyrrell, Vanessa, Haber, Michelle, Ziegler, David S., Vittorio, Orazio, Trapani, Joseph A., Cowley, Mark J., Neeson, Paul J., Ekert, Paul G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071693/
https://www.ncbi.nlm.nih.gov/pubmed/37013636
http://dx.doi.org/10.1186/s13073-023-01170-x

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