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Potential diagnostic value of N1LR and SNHG1 in acute myocardial infarction
INTRODUCTION: Acute myocardial infarction (AMI) is a common cardiovascular disease that can lead to myocardial necrosis and a poor prognosis. Clinical practice requires an accurate and quick diagnosis of AMI due to the inherent limitations of current biomarkers. Therefore, research into novel biomar...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071696/ https://www.ncbi.nlm.nih.gov/pubmed/37013574 http://dx.doi.org/10.1186/s12920-023-01501-2 |
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author | Zhu, Wei Luo, Li Ye, Guangning Ou, Jiaman |
author_facet | Zhu, Wei Luo, Li Ye, Guangning Ou, Jiaman |
author_sort | Zhu, Wei |
collection | PubMed |
description | INTRODUCTION: Acute myocardial infarction (AMI) is a common cardiovascular disease that can lead to myocardial necrosis and a poor prognosis. Clinical practice requires an accurate and quick diagnosis of AMI due to the inherent limitations of current biomarkers. Therefore, research into novel biomarkers is necessary. We aimed to explore the diagnostic potency of the long non-coding RNA (lncRNA) N1LR and SNHG1 in patients diagnosed with AMI. METHOD: We measured lncRNA levels in 148 AMI patients and 50 healthy volunteers with quantitative RT-PCR method. Receiver operating characteristic (ROC) analysis was administered to detect the diagnostic power of selected lncRNAs. Correlation analysis was performed to explore the relationship between N1LR as well as SNHG1 and the conventional myocardial biomarkers (LDH, CK, CKMB and cTnI). RESULTS: ROC analysis reveals the possibility of N1LR and SNHG1 as biomarkers in AMI diagnosis (AUC of N1LR: 0.873; AUC of SNHG1: 0.890). Correlation analysis revealed that N1LR was negatively correlated with the conventional biomarkers and SNHG1 was positively correlated with the conventional biomarkers. CONCLUSION: For the first time, we investigated the potential predictive diagnostic value of N1LR and SNHG1 in AMI diagnosis and substantial outcomes were obtained. Also, they may be capable of reflecting the progress of the disease during clinical practice from the correlation analysis. |
format | Online Article Text |
id | pubmed-10071696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-100716962023-04-05 Potential diagnostic value of N1LR and SNHG1 in acute myocardial infarction Zhu, Wei Luo, Li Ye, Guangning Ou, Jiaman BMC Med Genomics Research INTRODUCTION: Acute myocardial infarction (AMI) is a common cardiovascular disease that can lead to myocardial necrosis and a poor prognosis. Clinical practice requires an accurate and quick diagnosis of AMI due to the inherent limitations of current biomarkers. Therefore, research into novel biomarkers is necessary. We aimed to explore the diagnostic potency of the long non-coding RNA (lncRNA) N1LR and SNHG1 in patients diagnosed with AMI. METHOD: We measured lncRNA levels in 148 AMI patients and 50 healthy volunteers with quantitative RT-PCR method. Receiver operating characteristic (ROC) analysis was administered to detect the diagnostic power of selected lncRNAs. Correlation analysis was performed to explore the relationship between N1LR as well as SNHG1 and the conventional myocardial biomarkers (LDH, CK, CKMB and cTnI). RESULTS: ROC analysis reveals the possibility of N1LR and SNHG1 as biomarkers in AMI diagnosis (AUC of N1LR: 0.873; AUC of SNHG1: 0.890). Correlation analysis revealed that N1LR was negatively correlated with the conventional biomarkers and SNHG1 was positively correlated with the conventional biomarkers. CONCLUSION: For the first time, we investigated the potential predictive diagnostic value of N1LR and SNHG1 in AMI diagnosis and substantial outcomes were obtained. Also, they may be capable of reflecting the progress of the disease during clinical practice from the correlation analysis. BioMed Central 2023-04-03 /pmc/articles/PMC10071696/ /pubmed/37013574 http://dx.doi.org/10.1186/s12920-023-01501-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhu, Wei Luo, Li Ye, Guangning Ou, Jiaman Potential diagnostic value of N1LR and SNHG1 in acute myocardial infarction |
title | Potential diagnostic value of N1LR and SNHG1 in acute myocardial infarction |
title_full | Potential diagnostic value of N1LR and SNHG1 in acute myocardial infarction |
title_fullStr | Potential diagnostic value of N1LR and SNHG1 in acute myocardial infarction |
title_full_unstemmed | Potential diagnostic value of N1LR and SNHG1 in acute myocardial infarction |
title_short | Potential diagnostic value of N1LR and SNHG1 in acute myocardial infarction |
title_sort | potential diagnostic value of n1lr and snhg1 in acute myocardial infarction |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071696/ https://www.ncbi.nlm.nih.gov/pubmed/37013574 http://dx.doi.org/10.1186/s12920-023-01501-2 |
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