SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia

In acute myeloid leukemia (AML), SWI/SNF chromatin remodeling complexes sustain leukemic identity by driving high levels of MYC. Previous studies have implicated the hematopoietic transcription factor PU.1 (SPI1) as an important target of SWI/SNF inhibition, but PU.1 is widely regarded to have pione...

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Detalles Bibliográficos
Autores principales: Chambers, Courtney, Cermakova, Katerina, Chan, Yuen San, Kurtz, Kristen, Wohlan, Katharina, Lewis, Andrew Henry, Wang, Christiana, Pham, Anh, Dejmek, Milan, Sala, Michal, Loeza Cabrera, Mario, Aguilar, Rogelio, Nencka, Radim, Lacorazza, H. Daniel, Rau, Rachel E., Hodges, H. Courtney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Genome and Epigenome
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071820/
https://www.ncbi.nlm.nih.gov/pubmed/36662812
http://dx.doi.org/10.1158/0008-5472.CAN-22-2129

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