Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1

Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms of resistance to anti-GD2 therapy. Here, we show that reduced GD2 expression was significantly correlated with the mes...

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Detalles Bibliográficos
Autores principales: Mabe, Nathaniel W., Huang, Min, Dalton, Guillermo N., Alexe, Gabriela, Schaefer, Daniel A., Geraghty, Anna C., Robichaud, Amanda L., Conway, Amy S., Khalid, Delan, Mader, Marius M., Belk, Julia A., Ross, Kenneth N., Sheffer, Michal, Linde, Miles H., Ly, Nghi, Yao, Winnie, Rotiroti, Maria Caterina, Smith, Benjamin A. H., Wernig, Marius, Bertozzi, Carolyn R., Monje, Michelle, Mitsiades, Constantine S., Majeti, Ravindra, Satpathy, Ansuman T., Stegmaier, Kimberly, Majzner, Robbie G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071839/
https://www.ncbi.nlm.nih.gov/pubmed/35817829
http://dx.doi.org/10.1038/s43018-022-00405-x

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