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A review of research on the intersection between breast cancer and cardiovascular research in the Women’s Health Initiative (WHI)

Both obesity and metabolic syndrome are linked to increased incidence of type 2 diabetes, cardiovascular disease (CVD), and cancers of the breast (post-menopausal), and other obesity-related cancers. Over the past 50 years, the worldwide prevalence of obesity and metabolic syndrome has increased, wi...

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Autores principales: Raychaudhuri, Sreejata, Dieli-Conwright, Christina M., Cheng, Richard K., Barac, Ana, Reding, Kerryn W., Vasbinder, Alexi, Cook, Katherine L., Nair, Vidhya, Desai, Pinkal, Simon, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071996/
https://www.ncbi.nlm.nih.gov/pubmed/37025252
http://dx.doi.org/10.3389/fonc.2022.1039246
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author Raychaudhuri, Sreejata
Dieli-Conwright, Christina M.
Cheng, Richard K.
Barac, Ana
Reding, Kerryn W.
Vasbinder, Alexi
Cook, Katherine L.
Nair, Vidhya
Desai, Pinkal
Simon, Michael S.
author_facet Raychaudhuri, Sreejata
Dieli-Conwright, Christina M.
Cheng, Richard K.
Barac, Ana
Reding, Kerryn W.
Vasbinder, Alexi
Cook, Katherine L.
Nair, Vidhya
Desai, Pinkal
Simon, Michael S.
author_sort Raychaudhuri, Sreejata
collection PubMed
description Both obesity and metabolic syndrome are linked to increased incidence of type 2 diabetes, cardiovascular disease (CVD), and cancers of the breast (post-menopausal), and other obesity-related cancers. Over the past 50 years, the worldwide prevalence of obesity and metabolic syndrome has increased, with a concomitant higher incidence of associated co-morbidities and mortality. The precise mechanism linking metabolic syndrome to increased cancer incidence is incompletely understood, however, individual components of metabolic syndrome have been linked to increased breast cancer incidence and worse survival. There is a bidirectional relationship between the risk of CVD and cancer due to a high burden of shared risk factors and higher rates of CVD among cancer survivors, which may be impacted by the pro-inflammatory microenvironment associated with metabolic syndrome and cancer-directed therapies. The Women’s Health Initiative (WHI) is an excellent resource to study a dual relationship between cancer and CVD (cardio-oncology) with extensive information on risk factors and long-term outcomes. The purpose of this review is to provide an overview of research on cardio-oncology conducted utilizing WHI data with focus on studies evaluating both breast cancer and CVD including shared risk factors and outcomes after cancer. The review also includes results on other obesity related cancers which were included in the analyses of breast cancer, articles looking at cancer after heart disease (reverse cardio-oncology) and the role of Clonal Hematopoiesis of Indeterminate Potential (CHIP) as a shared risk factor between CVD and cancer. A summary of pertinent WHI literature helps to delineate the direction of future research evaluating the relationship between CVD and other cancer sites, and provides information on the opportunity for other novel analyses within the WHI.
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spelling pubmed-100719962023-04-05 A review of research on the intersection between breast cancer and cardiovascular research in the Women’s Health Initiative (WHI) Raychaudhuri, Sreejata Dieli-Conwright, Christina M. Cheng, Richard K. Barac, Ana Reding, Kerryn W. Vasbinder, Alexi Cook, Katherine L. Nair, Vidhya Desai, Pinkal Simon, Michael S. Front Oncol Oncology Both obesity and metabolic syndrome are linked to increased incidence of type 2 diabetes, cardiovascular disease (CVD), and cancers of the breast (post-menopausal), and other obesity-related cancers. Over the past 50 years, the worldwide prevalence of obesity and metabolic syndrome has increased, with a concomitant higher incidence of associated co-morbidities and mortality. The precise mechanism linking metabolic syndrome to increased cancer incidence is incompletely understood, however, individual components of metabolic syndrome have been linked to increased breast cancer incidence and worse survival. There is a bidirectional relationship between the risk of CVD and cancer due to a high burden of shared risk factors and higher rates of CVD among cancer survivors, which may be impacted by the pro-inflammatory microenvironment associated with metabolic syndrome and cancer-directed therapies. The Women’s Health Initiative (WHI) is an excellent resource to study a dual relationship between cancer and CVD (cardio-oncology) with extensive information on risk factors and long-term outcomes. The purpose of this review is to provide an overview of research on cardio-oncology conducted utilizing WHI data with focus on studies evaluating both breast cancer and CVD including shared risk factors and outcomes after cancer. The review also includes results on other obesity related cancers which were included in the analyses of breast cancer, articles looking at cancer after heart disease (reverse cardio-oncology) and the role of Clonal Hematopoiesis of Indeterminate Potential (CHIP) as a shared risk factor between CVD and cancer. A summary of pertinent WHI literature helps to delineate the direction of future research evaluating the relationship between CVD and other cancer sites, and provides information on the opportunity for other novel analyses within the WHI. Frontiers Media S.A. 2023-03-21 /pmc/articles/PMC10071996/ /pubmed/37025252 http://dx.doi.org/10.3389/fonc.2022.1039246 Text en Copyright © 2023 Raychaudhuri, Dieli-Conwright, Cheng, Barac, Reding, Vasbinder, Cook, Nair, Desai and Simon https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Raychaudhuri, Sreejata
Dieli-Conwright, Christina M.
Cheng, Richard K.
Barac, Ana
Reding, Kerryn W.
Vasbinder, Alexi
Cook, Katherine L.
Nair, Vidhya
Desai, Pinkal
Simon, Michael S.
A review of research on the intersection between breast cancer and cardiovascular research in the Women’s Health Initiative (WHI)
title A review of research on the intersection between breast cancer and cardiovascular research in the Women’s Health Initiative (WHI)
title_full A review of research on the intersection between breast cancer and cardiovascular research in the Women’s Health Initiative (WHI)
title_fullStr A review of research on the intersection between breast cancer and cardiovascular research in the Women’s Health Initiative (WHI)
title_full_unstemmed A review of research on the intersection between breast cancer and cardiovascular research in the Women’s Health Initiative (WHI)
title_short A review of research on the intersection between breast cancer and cardiovascular research in the Women’s Health Initiative (WHI)
title_sort review of research on the intersection between breast cancer and cardiovascular research in the women’s health initiative (whi)
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071996/
https://www.ncbi.nlm.nih.gov/pubmed/37025252
http://dx.doi.org/10.3389/fonc.2022.1039246
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