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Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity

Bispecific antibodies continue to represent a growth area for antibody therapeutics, with roughly a third of molecules in clinical development being T-cell engagers that use an anti-CD3 binding arm. CD3 antibodies possessing cross-reactivity with cynomolgus monkey typically recognize a highly electr...

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Detalles Bibliográficos
Autores principales:	Liu, Catherine Y, Ahonen, Cory L, Brown, Michael E, Zhou, Ling, Welin, Martin, Krauland, Eric M, Pejchal, Robert, Widboom, Paul F, Battles, Michael B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072072/ https://www.ncbi.nlm.nih.gov/pubmed/36991534 http://dx.doi.org/10.1080/19420862.2023.2189974

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