The applications of animal models in phage therapy: An update

The rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic agents. Among the current alternative therapies, phage therapy (PT) is promising. This review extensively summarizes preclinical PT approaches in various in-vivo models. PT has be...

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Autores principales: Mehmood Khan, Fazal, Manohar, Prasanth, Singh Gondil, Vijay, Mehra, Nancy, Kayode Oyejobi, Greater, Odiwuor, Nelson, Ahmad, Tauseef, Huang, Guangtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Novel Vaccines
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072079/
https://www.ncbi.nlm.nih.gov/pubmed/36935353
http://dx.doi.org/10.1080/21645515.2023.2175519
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author Mehmood Khan, Fazal
Manohar, Prasanth
Singh Gondil, Vijay
Mehra, Nancy
Kayode Oyejobi, Greater
Odiwuor, Nelson
Ahmad, Tauseef
Huang, Guangtao
author_facet Mehmood Khan, Fazal
Manohar, Prasanth
Singh Gondil, Vijay
Mehra, Nancy
Kayode Oyejobi, Greater
Odiwuor, Nelson
Ahmad, Tauseef
Huang, Guangtao
author_sort Mehmood Khan, Fazal
collection PubMed
description The rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic agents. Among the current alternative therapies, phage therapy (PT) is promising. This review extensively summarizes preclinical PT approaches in various in-vivo models. PT has been evaluated in several recent clinical trials. However, there are still several unanswered concerns due to a lack of appropriate regulation and pharmacokinetic data regarding the application of phages in human therapeutic procedures. In this review, we also presented the current state of PT and considered how animal models can be used to adapt these therapies for humans. The development of realistic solutions to circumvent these constraints is critical for advancing this technology.
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spelling pubmed-100720792023-04-05 The applications of animal models in phage therapy: An update Mehmood Khan, Fazal Manohar, Prasanth Singh Gondil, Vijay Mehra, Nancy Kayode Oyejobi, Greater Odiwuor, Nelson Ahmad, Tauseef Huang, Guangtao Hum Vaccin Immunother Novel Vaccines The rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic agents. Among the current alternative therapies, phage therapy (PT) is promising. This review extensively summarizes preclinical PT approaches in various in-vivo models. PT has been evaluated in several recent clinical trials. However, there are still several unanswered concerns due to a lack of appropriate regulation and pharmacokinetic data regarding the application of phages in human therapeutic procedures. In this review, we also presented the current state of PT and considered how animal models can be used to adapt these therapies for humans. The development of realistic solutions to circumvent these constraints is critical for advancing this technology. Taylor & Francis 2023-03-19 /pmc/articles/PMC10072079/ /pubmed/36935353 http://dx.doi.org/10.1080/21645515.2023.2175519 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Novel Vaccines
Mehmood Khan, Fazal
Manohar, Prasanth
Singh Gondil, Vijay
Mehra, Nancy
Kayode Oyejobi, Greater
Odiwuor, Nelson
Ahmad, Tauseef
Huang, Guangtao
The applications of animal models in phage therapy: An update
title The applications of animal models in phage therapy: An update
title_full The applications of animal models in phage therapy: An update
title_fullStr The applications of animal models in phage therapy: An update
title_full_unstemmed The applications of animal models in phage therapy: An update
title_short The applications of animal models in phage therapy: An update
title_sort applications of animal models in phage therapy: an update
topic Novel Vaccines
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072079/
https://www.ncbi.nlm.nih.gov/pubmed/36935353
http://dx.doi.org/10.1080/21645515.2023.2175519
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