The Relationship Between Sarcopenia, Cognitive Impairment, and Cerebral White Matter Hyperintensity in the Elderly

PURPOSE: To explore the relationship between sarcopenia-related indices, cognitive impairment and cerebral white matter hyperintensities. PATIENTS AND METHODS: Ninety-five hospitalized older adults aged 60 years and older were used in this study. Three sarcopenia-related indicators were measured: ha...

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Autores principales: Zhang, Kangrui, Zhang, Kangdi, Liu, Qiuwan, Wu, Juncang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072150/
https://www.ncbi.nlm.nih.gov/pubmed/37026080
http://dx.doi.org/10.2147/CIA.S404734
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author Zhang, Kangrui
Zhang, Kangdi
Liu, Qiuwan
Wu, Juncang
author_facet Zhang, Kangrui
Zhang, Kangdi
Liu, Qiuwan
Wu, Juncang
author_sort Zhang, Kangrui
collection PubMed
description PURPOSE: To explore the relationship between sarcopenia-related indices, cognitive impairment and cerebral white matter hyperintensities. PATIENTS AND METHODS: Ninety-five hospitalized older adults aged 60 years and older were used in this study. Three sarcopenia-related indicators were measured: hand grip strength (Measured with a spring-type dynamometer), gait speed (6m step speed method), and appendicular skeletal muscle mass (ASM, bioelectrical impedance). Sarcopenia was defined according to the Asian Working Group for Sarcopenia (AWGS) criteria. Cognitive function was assessed using Montreal Cognitive Assessment (MoCA). Cerebral white matter hyperintensity was assessed using 3.0T superconducting magnetic resonance imaging. RESULTS: In both men and women, these three indices of sarcopenia were significantly and negatively correlated with WMH grades, except for appendicular skeletal muscle mass and WMH grades in women. Scores on the MoCA scale were significantly positive correlated with grip strength, and ASM, both in men and women. After adjusting for confounders and WMHs, regression analyses showed an increased incidence of cognitive impairment in patients with sarcopenia relative to those without sarcopenia. CONCLUSION: Lower sarcopenia-related indices were significantly associated with cognitive impairment. WMHs may be one of the factors linking sarcopenia and cognitive function.
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spelling pubmed-100721502023-04-05 The Relationship Between Sarcopenia, Cognitive Impairment, and Cerebral White Matter Hyperintensity in the Elderly Zhang, Kangrui Zhang, Kangdi Liu, Qiuwan Wu, Juncang Clin Interv Aging Original Research PURPOSE: To explore the relationship between sarcopenia-related indices, cognitive impairment and cerebral white matter hyperintensities. PATIENTS AND METHODS: Ninety-five hospitalized older adults aged 60 years and older were used in this study. Three sarcopenia-related indicators were measured: hand grip strength (Measured with a spring-type dynamometer), gait speed (6m step speed method), and appendicular skeletal muscle mass (ASM, bioelectrical impedance). Sarcopenia was defined according to the Asian Working Group for Sarcopenia (AWGS) criteria. Cognitive function was assessed using Montreal Cognitive Assessment (MoCA). Cerebral white matter hyperintensity was assessed using 3.0T superconducting magnetic resonance imaging. RESULTS: In both men and women, these three indices of sarcopenia were significantly and negatively correlated with WMH grades, except for appendicular skeletal muscle mass and WMH grades in women. Scores on the MoCA scale were significantly positive correlated with grip strength, and ASM, both in men and women. After adjusting for confounders and WMHs, regression analyses showed an increased incidence of cognitive impairment in patients with sarcopenia relative to those without sarcopenia. CONCLUSION: Lower sarcopenia-related indices were significantly associated with cognitive impairment. WMHs may be one of the factors linking sarcopenia and cognitive function. Dove 2023-03-31 /pmc/articles/PMC10072150/ /pubmed/37026080 http://dx.doi.org/10.2147/CIA.S404734 Text en © 2023 Zhang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhang, Kangrui
Zhang, Kangdi
Liu, Qiuwan
Wu, Juncang
The Relationship Between Sarcopenia, Cognitive Impairment, and Cerebral White Matter Hyperintensity in the Elderly
title The Relationship Between Sarcopenia, Cognitive Impairment, and Cerebral White Matter Hyperintensity in the Elderly
title_full The Relationship Between Sarcopenia, Cognitive Impairment, and Cerebral White Matter Hyperintensity in the Elderly
title_fullStr The Relationship Between Sarcopenia, Cognitive Impairment, and Cerebral White Matter Hyperintensity in the Elderly
title_full_unstemmed The Relationship Between Sarcopenia, Cognitive Impairment, and Cerebral White Matter Hyperintensity in the Elderly
title_short The Relationship Between Sarcopenia, Cognitive Impairment, and Cerebral White Matter Hyperintensity in the Elderly
title_sort relationship between sarcopenia, cognitive impairment, and cerebral white matter hyperintensity in the elderly
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072150/
https://www.ncbi.nlm.nih.gov/pubmed/37026080
http://dx.doi.org/10.2147/CIA.S404734
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