Enhancing Efficacy of TCR-engineered CD4(+) T Cells Via Coexpression of CD8α

Adoptive cell therapy with T cells expressing affinity-enhanced T-cell receptors (TCRs) is a promising treatment for solid tumors. Efforts are ongoing to further engineer these T cells to increase the depth and durability of clinical responses and broaden efficacy toward additional indications. In t...

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Detalles Bibliográficos
Autores principales: Anderson, Victoria E., Brilha, Sara S., Weber, Anika M., Pachnio, Annette, Wiedermann, Guy E., Dauleh, Sumaya, Ahmed, Tina, Pope, George R., Quinn, Laura L., Docta, Roslin Y., Quattrini, Adriano, Masters, Siobhan, Cartwright, Neil, Viswanathan, Preetha, Melchiori, Luca, Rice, Louise V., Sevko, Alexandra, Gueguen, Claire, Saini, Manoj, Tavano, Barbara, Abbott, Rachel J.M., Silk, Jonathan D., Laugel, Bruno, Sanderson, Joseph P., Gerry, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Basic Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10072215/
https://www.ncbi.nlm.nih.gov/pubmed/36826388
http://dx.doi.org/10.1097/CJI.0000000000000456

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